Seroatlas · Human Serome Atlas

TBRG1

Transforming growth factor beta regulator 1

Also known as: FLJ14621, NIAM, TB-5, TBRG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3YBR2
Gene: TBRG1
Ensembl: ENSG00000154144
Chromosome: 11
Canonical length: 411 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Involved in several processes, including DNA replication; protein localization to nucleoplasm; and protein stabilization. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

411 residues, UniProt reviewed canonical sequence.

>Q3YBR2|TBRG1
     1  MSLLDGLASS PRAPLQSSKA RMKKLPKKSQ NEKYRLKYLR LRKAAKATVF ENAAICDEIA
    61  RLEEKFLKAK EERRYLLKKL LQLQALTEGE VQAAAPSHSS SLPLTYGVAS SVGTIQGAGP
   121  ISGPSTGAEE PFGKKTKKEK KEKGKENNKL EVLKKTCKKK KMAGGARKLV QPIALDPSGR
   181  PVFPIGLGGL TVYSLGEIIT DRPGFHDESA IYPVGYCSTR IYASMKCPDQ KCLYTCQIKD
   241  GGVQPQFEIV PEDDPQNAIV SSSADACHAE LLRTISTTMG KLMPNLLPAG ADFFGFSHPA
   301  IHNLIQSCPG ARKCINYQWV KFDVCKPGDG QLPEGLPEND AAMSFEAFQR QIFDEDQNDP
   361  LLPGSLDLPE LQPAAFVSSY QPMYLTHEPL VDTHLQHLKS PSQGSPIQSS D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBRG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 6.5 nTPM

Expression across tissuesHPA

Tissue

spleen: 6.5 nTPM
lymph node: 6 nTPM
duodenum: 5.8 nTPM
tonsil: 5.7 nTPM
skeletal muscle: 5.6 nTPM
appendix: 5.1 nTPM

Single-cell type

adrenal cortex cells: 222 nCPM
enterocytes: 182 nCPM
leydig cells: 181 nCPM
epididymal principal cells: 168 nCPM
t-cells: 142 nCPM
foveolar cells: 136 nCPM

Immune cell

eosinophil: 35 nTPM
memory B-cell: 34 nTPM
neutrophil: 33 nTPM
basophil: 31 nTPM
naive B-cell: 31 nTPM
T-reg: 28 nTPM

Brain region

basal ganglia: 13 nTPM
cerebral cortex: 8.9 nTPM
white matter: 8.1 nTPM
hippocampal formation: 7.6 nTPM
hypothalamus: 7.1 nTPM
amygdala: 6.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TBRG1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 74 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: 0.81
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

FY-rich, N-terminal
FY-rich, C-terminal
F/Y-rich N-terminus
F/Y rich C-terminus
Transforming growth factor beta regulator 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TBRG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBRG1 as an antibody target. Whether an autoantibody or antibody against TBRG1 could matter depends on whether native TBRG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBRG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBRG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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