Seroatlas · Human Serome Atlas

DYNLT5

Dynein light chain Tctex-type 5

Also known as: DYLT5_HUMAN, FLJ40873, TCTEX1D1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N7M0
Gene: DYNLT5
Ensembl: ENSG00000152760
Chromosome: 1
Canonical length: 179 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

179 residues, UniProt reviewed canonical sequence.

>Q8N7M0|DYNLT5
     1  MMMSDNAKGR AAHSWKKRGS ISSLSNHEFW RKEIHGRIKD SMSTVSYMEE PSQRDDISRL
    61  TVQMENTYQL GPPKHFPVVT VNHILKDVVT SYLQVEEYEP ELCRQMTKTI SEVIKAQVKD
   121  LMIPRYKLIV IVHIGQLNRQ SILIGSRCLW DPKSDTFSSY VFRNSSLFAL ANVYAVYLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DYNLT5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 13 nTPM
fallopian tube: 8.4 nTPM
hypothalamus: 6.9 nTPM
liver: 6.6 nTPM
placenta: 5.4 nTPM
hippocampal formation: 5.3 nTPM

Single-cell type

ependymal cells: 841 nCPM
respiratory ciliated cells: 279 nCPM
epididymal efferent duct ciliated cells: 220 nCPM
fallopian tube ciliated cells: 202 nCPM
choroid plexus epithelial cells: 195 nCPM
hematopoietic stem cells: 111 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 12 nTPM
medulla oblongata: 12 nTPM
midbrain: 10 nTPM
white matter: 8.3 nTPM
spinal cord: 7.8 nTPM
pons: 5.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.57
gnomAD pLI: 0
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

microtubule-based movement

Molecular functions

dynein intermediate chain binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of DYNLT5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ZMYND10

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DYNLT5 as an antibody target. Whether an autoantibody or antibody against DYNLT5 could matter depends on whether native DYNLT5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DYNLT5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DYNLT5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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