Seroatlas · Human Serome Atlas

ZC3H14

Zinc finger CCCH domain-containing protein 14

Also known as: FLJ11806, NY-REN-37, UKp68, ZC3HE_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PJT7
Gene: ZC3H14
Ensembl: ENSG00000100722
Chromosome: 14
Canonical length: 736 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoli,Nucleoli rim,Nuclear speckles
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a poly(A)-binding protein that can affect gene expression and poly(A) tail length. The encoded protein may influence mRNA stability, nuclear export, and translation. [provided by RefSeq, May 2016]

Canonical amino-acid sequenceUniProt

736 residues, UniProt reviewed canonical sequence.

>Q6PJT7|ZC3H14
     1  MEIGTEISRK IRSAIKGKLQ ELGAYVDEEL PDYIMVMVAN KKSQDQMTED LSLFLGNNTI
    61  RFTVWLHGVL DKLRSVTTEP SSLKSSDTNI FDSNVPSNKS NFSRGDERRH EAAVPPLAIP
   121  SARPEKRDSR VSTSSQESKT TNVRQTYDDG AATRLMSTVK PLREPAPSED VIDIKPEPDD
   181  LIDEDLNFVQ ENPLSQKKPT VTLTYGSSRP SIEIYRPPAS RNADSGVHLN RLQFQQQQNS
   241  IHAAKQLDMQ SSWVYETGRL CEPEVLNSLE ETYSPFFRNN SEKMSMEDEN FRKRKLPVVS
   301  SVVKVKKFNH DGEEEEEDDD YGSRTGSISS SVSVPAKPER RPSLPPSKQA NKNLILKAIS
   361  EAQESVTKTT NYSTVPQKQT LPVAPRTRTS QEELLAEVVQ GQSRTPRISP PIKEEETKGD
   421  SVEKNQGTQQ RQLLSRLQID PVMAETLQMS QDYYDMESMV HADTRSFILK KPKLSEEVVV
   481  APNQESGMKT ADSLRVLSGH LMQTRDLVQP DKPASPKFIV TLDGVPSPPG YMSDQEEDMC
   541  FEGMKPVNQT AASNKGLRGL LHPQQLHLLS RQLEDPNGSF SNAEMSELSV AQKPEKLLER
   601  CKYWPACKNG DECAYHHPIS PCKAFPNCKF AEKCLFVHPN CKYDAKCTKP DCPFTHVSRR
   661  IPVLSPKPAV APPAPPSSSQ LCRYFPACKK MECPFYHPKH CRFNTQCTRP DCTFYHPTIN
   721  VPPRHALKWI RPQTSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC3H14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 162 nTPM

Expression across tissuesHPA

Tissue

testis: 162 nTPM
choroid plexus: 39 nTPM
retina: 38 nTPM
pancreas: 35 nTPM
liver: 34 nTPM
parathyroid gland: 31 nTPM

Single-cell type

early spermatids: 1,427 nCPM
late primary spermatocytes: 916 nCPM
late spermatids: 600 nCPM
choroid plexus epithelial cells: 219 nCPM
sertoli cells: 210 nCPM
lactotrophs: 175 nCPM

Immune cell

non-classical monocyte: 30 nTPM
eosinophil: 29 nTPM
NK-cell: 26 nTPM
intermediate monocyte: 25 nTPM
myeloid DC: 22 nTPM
memory CD8 T-cell: 21 nTPM

Brain region

choroid plexus: 131 nTPM
cerebellum: 104 nTPM
cerebral cortex: 79 nTPM
white matter: 76 nTPM
amygdala: 68 nTPM
hypothalamus: 67 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZC3H14.

Disease | AllUniProt

Conditions ZC3H14 is implicated in, by any mechanism.

Intellectual developmental disorder, autosomal recessive 56 (MRT56) MIM:617125

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.88
gnomAD missense Z: 1.45
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, CCCH-type
RNA-binding, Nab2-type zinc finger
Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZC3H14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC3H14 as an antibody target. Whether an autoantibody or antibody against ZC3H14 could matter depends on whether native ZC3H14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC3H14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC3H14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...