Seroatlas · Human Serome Atlas

ACOT12

Acetyl-coenzyme A thioesterase

Also known as: ACO12_HUMAN, Cach, STARD15, THEAL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WYK0
Gene: ACOT12
Ensembl: ENSG00000172497
Chromosome: 5
Canonical length: 555 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Cytokinetic bridge,Cytosol
Quaternary structure: Homotetramer

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in acetyl-CoA metabolic process. Located in cytosol; intercellular bridge; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

555 residues, UniProt reviewed canonical sequence.

>Q8WYK0|ACOT12
     1  MERPAPGEVV MSQAIQPAHA TARGELSAGQ LLKWIDTTAC LAAEKHAGVS CVTASVDDIQ
    61  FEETARVGQV ITIKAKVTRA FSTSMEISIK VMVQDMLTGI EKLVSVAFST FVAKPVGKEK
   121  IHLKPVTLLT EQDHVEHNLA AERRKVRLQH EDTFNNLMKE SSKFDDLIFD EEEGAVSTRG
   181  TSVQSIELVL PPHANHHGNT FGGQIMAWME TVATISASRL CWAHPFLKSV DMFKFRGPST
   241  VGDRLVFTAI VNNTFQTCVE VGVRVEAFDC QEWAEGRGRH INSAFLIYNA ADDKENLITF
   301  PRIQPISKDD FRRYRGAIAR KRIRLGRKYV ISHKEEVPLC IHWDISKQAS LSDSNVEALK
   361  KLAAKRGWEV TSTVEKIKIY TLEEHDVLSV WVEKHVGSPA HLAYRLLSDF TKRPLWDPHF
   421  VSCEVIDWVS EDDQLYHITC PILNDDKPKD LVVLVSRRKP LKDGNTYTVA VKSVILPSVP
   481  PSPQYIRSEI ICAGFLIHAI DSNSCIVSYF NHMSASILPY FAGNLGGWSK SIEETAASCI
   541  QFLENPPDDG FVSTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACOT12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 94 nTPM

Expression across tissuesHPA

Tissue

liver: 94 nTPM
kidney: 2.5 nTPM
small intestine: 0.7 nTPM
duodenum: 0.3 nTPM
epididymis: 0.3 nTPM
hypothalamus: 0.2 nTPM

Single-cell type

hepatocytes: 80 nCPM
thymocytes: 66 nCPM
renal collecting duct principal cells: 19 nCPM
pdcs: 15 nCPM
hepatic stellate cells: 13 nCPM
proximal tubule cells: 9.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 2 nTPM
pons: 2 nTPM
hypothalamus: 1.9 nTPM
cerebral cortex: 1.6 nTPM
amygdala: 1.4 nTPM
midbrain: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.05
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACOT12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ZBTB8A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACOT12 as an antibody target. Whether an autoantibody or antibody against ACOT12 could matter depends on whether native ACOT12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACOT12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACOT12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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