Seroatlas · Human Serome Atlas

ZNF639

Zinc finger protein 639

Also known as: ANC-2H01, ZASC1, ZN639_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UID6
Gene
ZNF639
Ensembl
ENSG00000121864
Chromosome
3
Canonical length
485 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the Kruppel-like zinc finger family of proteins. Amplification and overexpression of this gene have been observed in esophageal squamous cell carcinoma. The encoded protein has been shown to bind DNA in a sequence-specific manner and may regulate HIV-1 gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

485 residues, UniProt reviewed canonical sequence.

>Q9UID6|ZNF639
     1  MNEYPKKRKR KTLHPSRYSD SSGISRIADG FNGIFSDHCY SVCSMRQPDL KYFDNKDDDS
    61  DTETSNDLPK FADGIKARNR NQNYLVPSPV LRILDHTAFS TEKSADIVIC DEECDSPESV
   121  NQQTQEESPI EVHTAEDVPI AVEVHAISED YDIETENNSS ESLQDQTDEE PPAKLCKILD
   181  KSQALNVTAQ QKWPLLRANS SGLYKCELCE FNSKYFSDLK QHMILKHKRT DSNVCRVCKE
   241  SFSTNMLLIE HAKLHEEDPY ICKYCDYKTV IFENLSQHIA DTHFSDHLYW CEQCDVQFSS
   301  SSELYLHFQE HSCDEQYLCQ FCEHETNDPE DLHSHVVNEH ACKLIELSDK YNNGEHGQYS
   361  LLSKITFDKC KNFFVCQVCG FRSRLHTNVN RHVAIEHTKI FPHVCDDCGK GFSSMLEYCK
   421  HLNSHLSEGI YLCQYCEYST GQIEDLKIHL DFKHSADLPH KCSDCLMRFG NERELISHLP
   481  VHETT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF639 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
56 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 56 nTPM
  • thyroid gland: 39 nTPM
  • retina: 37 nTPM
  • parathyroid gland: 36 nTPM
  • endometrium: 29 nTPM
  • blood vessel: 29 nTPM

Single-cell type

  • cone photoreceptor cells: 58 nCPM
  • rod photoreceptor cells: 44 nCPM
  • megakaryocytes: 43 nCPM
  • erythrocyte progenitors: 40 nCPM
  • endometrial luminal cells: 39 nCPM
  • late primary spermatocytes: 38 nCPM

Immune cell

  • memory CD4 T-cell: 2.6 nTPM
  • memory CD8 T-cell: 2.6 nTPM
  • T-reg: 2.4 nTPM
  • basophil: 2.3 nTPM
  • naive CD8 T-cell: 2.3 nTPM
  • naive CD4 T-cell: 2.2 nTPM

Brain region

  • cerebellum: 36 nTPM
  • white matter: 27 nTPM
  • thalamus: 27 nTPM
  • basal ganglia: 26 nTPM
  • cerebral cortex: 25 nTPM
  • spinal cord: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
gnomAD missense Z
1.27
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF639 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF639 as an antibody target. Whether an autoantibody or antibody against ZNF639 could matter depends on whether native ZNF639 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF639 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF639 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF639. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...