Seroatlas · Human Serome Atlas

YIPF5

Protein YIPF5

Also known as: FinGER5, SMAP-5, YIPF5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q969M3
Gene
YIPF5
Ensembl
ENSG00000145817
Chromosome
5
Canonical length
257 aa
Protein class
Disease related genes, Human disease related genes, Predicted membrane proteins
Subcellular location
Nucleoplasm,Endoplasmic reticulum,Golgi apparatus,Vesicles

OverviewNCBI Gene

Involved in insulin processing and regulation of ER to Golgi vesicle-mediated transport. Located in Golgi apparatus; endoplasmic reticulum; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

257 residues, UniProt reviewed canonical sequence.

>Q969M3|YIPF5
     1  MSGFENLNTD FYQTSYSIDD QSQQSYDYGG SGGPYSKQYA GYDYSQQGRF VPPDMMQPQQ
    61  PYTGQIYQPT QAYTPASPQP FYGNNFEDEP PLLEELGINF DHIWQKTLTV LHPLKVADGS
   121  IMNETDLAGP MVFCLAFGAT LLLAGKIQFG YVYGISAIGC LGMFCLLNLM SMTGVSFGCV
   181  ASVLGYCLLP MILLSSFAVI FSLQGMVGII LTAGIIGWCS FSASKIFISA LAMEGQQLLV
   241  AYPCALLYGV FALISVF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YIPF5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
5
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 30 nTPM
  • liver: 30 nTPM
  • duodenum: 29 nTPM
  • placenta: 28 nTPM
  • esophagus: 27 nTPM
  • smooth muscle: 27 nTPM

Single-cell type

  • esophageal apical cells: 131 nCPM
  • extravillous trophoblasts: 115 nCPM
  • pancreatic acinar cells: 95 nCPM
  • syncytiotrophoblasts: 85 nCPM
  • epididymal principal cells: 81 nCPM
  • early primary spermatocytes: 80 nCPM

Immune cell

  • T-reg: 63 nTPM
  • MAIT T-cell: 53 nTPM
  • memory CD8 T-cell: 52 nTPM
  • naive CD4 T-cell: 49 nTPM
  • basophil: 49 nTPM
  • eosinophil: 49 nTPM

Brain region

  • choroid plexus: 34 nTPM
  • hypothalamus: 25 nTPM
  • white matter: 24 nTPM
  • pons: 24 nTPM
  • spinal cord: 21 nTPM
  • midbrain: 21 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about YIPF5.

Disease | AllUniProt

Conditions YIPF5 is implicated in, by any mechanism.

  • Microcephaly, epilepsy, and diabetes syndrome 2 (MEDS2) MIM:619278

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 48 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Microcephaly, epilepsy, and diabetes syndrome 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
0.99
gnomAD missense Z
0.68
DepMap mean gene effect
-0.25
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of YIPF5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YIPF5 as an antibody target. Whether an autoantibody or antibody against YIPF5 could matter depends on whether native YIPF5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YIPF5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YIPF5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/YIPF5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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