Seroatlas · Human Serome Atlas

TMEM17

Transmembrane protein 17

Also known as: FLJ34583, TMM17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86X19
Gene: TMEM17
Ensembl: ENSG00000186889
Chromosome: 2
Canonical length: 198 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus,Actin filaments

OverviewNCBI Gene

Involved in non-motile cilium assembly. Predicted to be located in ciliary membrane. Predicted to be part of MKS complex. Predicted to be active in ciliary transition zone. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>Q86X19|TMEM17
     1  MELPDPVRQR LGNFSRAVFS DSNRTGPESN EGPENEMVSS LALQMSLYFN TYYFPLWWVS
    61  SIMMLHMKYS ILPDYYKFIV ITVIILITLI EAIRLYLGYV GNLQEKVPEL AGFWLLSLLL
   121  QLPLILFLLF NEGLTNLPLE KAIHIIFTLF LAFQVVAAFL TLRKMVNQLA VRFHLQDFDR
   181  LSANRGDMRR MRSCIEEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 11 nTPM
basal ganglia: 7.6 nTPM
choroid plexus: 7.3 nTPM
parathyroid gland: 5.7 nTPM
hippocampal formation: 4.9 nTPM
adrenal gland: 4.7 nTPM

Single-cell type

early primary spermatocytes: 40 nCPM
epididymal efferent duct ciliated cells: 24 nCPM
fallopian tube ciliated cells: 23 nCPM
respiratory ciliated cells: 23 nCPM
platelets: 23 nCPM
other brain neurons: 22 nCPM

Immune cell

plasmacytoid DC: 1.9 nTPM
basophil: 0.5 nTPM
myeloid DC: 0.5 nTPM
neutrophil: 0.5 nTPM
total PBMC: 0.4 nTPM
NK-cell: 0.3 nTPM

Brain region

hypothalamus: 20 nTPM
pons: 12 nTPM
midbrain: 12 nTPM
choroid plexus: 10 nTPM
medulla oblongata: 9.7 nTPM
hippocampal formation: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0.01
gnomAD missense Z: 0.41
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

YIF1A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM17 as an antibody target. Whether an autoantibody or antibody against TMEM17 could matter depends on whether native TMEM17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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