POLE4
DNA polymerase epsilon subunit 4
Also known as: DPOE4_HUMAN, p12
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NR33
- Gene
- POLE4
- Ensembl
- ENSG00000115350
- Chromosome
- 2
- Canonical length
- 117 aa
- Protein class
- FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
Canonical amino-acid sequenceUniProt
117 residues, UniProt reviewed canonical sequence.
>Q9NR33|POLE4
1 MAAAAAAGSG TPREEEGPAG EAAASQPQAP TSVPGARLSR LPLARVKALV KADPDVTLAG
61 QEAIFILARA AELFVETIAK DAYCCAQQGK RKTLQRRDLD NAIEAVDEFA FLEGTLDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against POLE4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.52
- Highest tissue expression
- 38 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 38 nTPM
- amygdala: 36 nTPM
- cerebral cortex: 31 nTPM
- blood vessel: 30 nTPM
- basal ganglia: 25 nTPM
- adipose tissue: 25 nTPM
Single-cell type
- oocytes: 368 nCPM
- parietal cells: 324 nCPM
- cytotrophoblasts: 191 nCPM
- extravillous trophoblasts: 184 nCPM
- migrating cytotrophoblasts: 173 nCPM
- esophageal suprabasal cells: 173 nCPM
Immune cell
- classical monocyte: 53 nTPM
- memory B-cell: 35 nTPM
- plasmacytoid DC: 34 nTPM
- naive B-cell: 33 nTPM
- intermediate monocyte: 33 nTPM
- total PBMC: 32 nTPM
Brain region
- white matter: 12 nTPM
- cerebral cortex: 9.7 nTPM
- basal ganglia: 9.6 nTPM
- pons: 9.3 nTPM
- thalamus: 8.8 nTPM
- amygdala: 8.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.68
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.33
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of POLE4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads POLE4 as an antibody target. Whether an autoantibody or antibody against POLE4 could matter depends on whether native POLE4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
POLE4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label POLE4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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