Seroatlas · Human Serome Atlas

CDKN2AIPNL

CDKN2AIP N-terminal-like protein

Also known as: C2AIL, C2AIL_HUMAN, MGC13017

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96HQ2
Gene: CDKN2AIPNL
Ensembl: ENSG00000237190
Chromosome: 5
Canonical length: 116 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CDKN2AIPNL in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

116 residues, UniProt reviewed canonical sequence.

>Q96HQ2|CDKN2AIPNL
     1  MVGGEAAAAV EELVSGVRQA ADFAEQFRSY SESEKQWKAR MEFILRHLPD YRDPPDGSGR
    61  LDQLLSLSMV WANHLFLGCS YNKDLLDKVM EMADGIEVED LPQFTTRSEL MKKHQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDKN2AIPNL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 76 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 76 nTPM
tongue: 40 nTPM
cerebral cortex: 35 nTPM
heart muscle: 33 nTPM
pancreas: 31 nTPM
hypothalamus: 26 nTPM

Single-cell type

late spermatids: 66 nCPM
oocytes: 55 nCPM
migrating cytotrophoblasts: 47 nCPM
esophageal basal cells: 47 nCPM
extravillous trophoblasts: 46 nCPM
cytotrophoblasts: 46 nCPM

Immune cell

memory B-cell: 30 nTPM
naive B-cell: 28 nTPM
T-reg: 25 nTPM
plasmacytoid DC: 24 nTPM
memory CD4 T-cell: 23 nTPM
MAIT T-cell: 23 nTPM

Brain region

cerebral cortex: 42 nTPM
pons: 40 nTPM
medulla oblongata: 40 nTPM
hypothalamus: 38 nTPM
basal ganglia: 35 nTPM
cerebellum: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0.34
gnomAD missense Z: -0.26
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Acetylation

InteractionsUniProt · HPA

Protein binding partners of CDKN2AIPNL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

XRN2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDKN2AIPNL as an antibody target. Whether an autoantibody or antibody against CDKN2AIPNL could matter depends on whether native CDKN2AIPNL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDKN2AIPNL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDKN2AIPNL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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