Seroatlas · Human Serome Atlas

SFRP1

Secreted frizzled-related protein 1

Also known as: FRP, FRP-1, SARP2, SFRP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N474
Gene
SFRP1
Ensembl
ENSG00000104332
Chromosome
8
Canonical length
314 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins, Transporters
Secretome location
Secreted in other tissues

OverviewNCBI Gene

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

314 residues, UniProt reviewed canonical sequence.

>Q8N474|SFRP1
     1  MGIGRSEGGR RGAALGVLLA LGAALLAVGS ASEYDYVSFQ SDIGPYQSGR FYTKPPQCVD
    61  IPADLRLCHN VGYKKMVLPN LLEHETMAEV KQQASSWVPL LNKNCHAGTQ VFLCSLFAPV
   121  CLDRPIYPCR WLCEAVRDSC EPVMQFFGFY WPEMLKCDKF PEGDVCIAMT PPNATEASKP
   181  QGTTVCPPCD NELKSEAIIE HLCASEFALR MKIKEVKKEN GDKKIVPKKK KPLKLGPIKK
   241  KDLKKLVLYL KNGADCPCHQ LDNLSHHFLI MGRKVKSQYL LTAIHKWDKK NKEFKNFMKK
   301  MKNHECPTFQ SVFK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SFRP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
650 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 650 nTPM
  • breast: 280 nTPM
  • salivary gland: 223 nTPM
  • cervix: 191 nTPM
  • endometrium: 124 nTPM
  • heart muscle: 117 nTPM

Single-cell type

  • lacrimal acinar cells: 1,663 nCPM
  • breast secretory cells: 1,533 nCPM
  • breast myoepithelial cells: 654 nCPM
  • salivary acinar cells: 542 nCPM
  • salivary myoepithelial cells: 520 nCPM
  • leydig cells: 479 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 1,107 nTPM
  • hippocampal formation: 58 nTPM
  • pons: 55 nTPM
  • white matter: 43 nTPM
  • cerebellum: 31 nTPM
  • medulla oblongata: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.96
gnomAD missense Z
1.31
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SFRP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SFRP1 as an antibody target. Whether an autoantibody or antibody against SFRP1 could matter depends on whether native SFRP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SFRP1 is annotated as secreted, so native SFRP1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SFRP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SFRP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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