Seroatlas · Human Serome Atlas

RSPO3

R-spondin-3

Also known as: FLJ14440, RSPO3_HUMAN, THSD2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXY4
Gene: RSPO3
Ensembl: ENSG00000146374
Chromosome: 6
Canonical length: 272 aa
Protein class: Cancer-related genes, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

272 residues, UniProt reviewed canonical sequence.

>Q9BXY4|RSPO3
     1  MHLRLISWLF IILNFMEYIG SQNASRGRRQ RRMHPNVSQG CQGGCATCSD YNGCLSCKPR
    61  LFFALERIGM KQIGVCLSSC PSGYYGTRYP DINKCTKCKA DCDTCFNKNF CTKCKSGFYL
   121  HLGKCLDNCP EGLEANNHTM ECVSIVHCEV SEWNPWSPCT KKGKTCGFKR GTETRVREII
   181  QHPSAKGNLC PPTNETRKCT VQRKKCQKGE RGKKGRERKR KKPNKGESKE AIPDSKSLES
   241  SKEIPEQREN KQQQKKRKVQ DKQKSVSVST VH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RSPO3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

smooth muscle: 45 nTPM
endometrium: 40 nTPM
skeletal muscle: 37 nTPM
placenta: 33 nTPM
epididymis: 27 nTPM
fallopian tube: 23 nTPM

Single-cell type

adipocytes: 100 nCPM
fibroblasts: 94 nCPM
myonuclei: 90 nCPM
fibro-adipogenic progenitors: 88 nCPM
corticotrophs: 36 nCPM
vascular endothelial cells: 35 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hippocampal formation: 20 nTPM
cerebral cortex: 13 nTPM
cerebellum: 8.7 nTPM
basal ganglia: 6.7 nTPM
amygdala: 6.4 nTPM
medulla oblongata: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0.09
gnomAD missense Z: 1.02
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RSPO3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RSPO3 as an antibody target. Whether an autoantibody or antibody against RSPO3 could matter depends on whether native RSPO3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RSPO3 is annotated as secreted, so native RSPO3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label RSPO3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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