Seroatlas · Human Serome Atlas

TECPR1

Tectonin beta-propeller repeat-containing protein 1

Also known as: DKFZP434B0335, FLJ23419, FLJ90593, KIAA1358, TCPR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z6L1
Gene: TECPR1
Ensembl: ENSG00000205356
Chromosome: 7
Canonical length: 1165 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

1165 residues, UniProt reviewed canonical sequence.

>Q7Z6L1|TECPR1
     1  MPNSVLWAVD LFGRVYTLST AGQYWEMCKD SQLEFKRVSA TTQCCWGIAC DNQVYVYVCA
    61  SDVPIRRREE AYENQRWNPM GGFCEKLLLS DRWGWSDVSG LQHRPLDRVA LPSPHWEWES
   121  DWYVDENFGG EPTEKGGWTY AIDFPATYTK DKKWNSCVRR RKWIRYRRYK SRDIWAKIPS
   181  KDDPKELPDP FNDLSVGGWE ITEEPVGRLS VWAVSLQGKV WYREDVSHSN PEGSSWSLLD
   241  TPGEVVQISC GPHDLLWATL WEGQALVREG INRSNPKGSS WSIVEPPGSE NGVMHISVGV
   301  SVVWAVTKDW KVWFRRGVNS HNPCGTSWIE MVGEMTMVNV GMNDQVWGIG CEDRAVYFRQ
   361  GVTPSELSGK TWKAIIAARE CDRSHSGSSS SLLSAGCFFG DEVRGSGESA PSDTDASSEV
   421  ERPGPGQILP AEPLDDSKNA TGNSASGLGA GRTAEDTVED ACPAEGSREA RPNTHPGPAP
   481  TPAELPWTNI DLKEAKKVPS HSAAGFPETT SLSSLGLLPL GLEEPYGVDD HPLWAWVSGG
   541  GCVVEACAMP RWFTVQAGLS SSVHMLSLSI TPAQTAAWRK QIFQQLTERT KRELENFRHY
   601  EQAVEQSVWV KTGALQWWCD WKPHKWVDVR LALEQFTGHD GVRDSILFIY YVVHEEKKYI
   661  HIFLNEVVAL VPVLNETKHS FALYTPERTR QRWPVRLAAA TEQDMNDWLA LLSLSCCESR
   721  KVQGRPSPQA IWSITCKGDI FVSEPSPDLE AHEHPLPCDQ MFWRQMGGHL RMVEANSRGV
   781  VWGIGYDHTA WVYTGGYGGG CFQGLASSTS NIYTQSDVKC VHIYENQRWN PVTGYTSRGL
   841  PTDRYMWSDA SGLQECTKAG TKPPSLQWAW VSDWFVDFSV PGGTDQEGWQ YASDFPASYH
   901  GSKTMKDFVR RRCWARKCKL VTSGPWLEVP PIALRDVSII PESPGAEGSG HSIALWAVSD
   961  KGDVLCRLGV SELNPAGSSW LHVGTDQPFA SISIGACYQV WAVARDGSAF YRGSVYPSQP
  1021  AGDCWYHIPS PPRQRLKQVS AGQTSVYALD ENGNLWYRQG ITPSYPQGSS WEHVSNNVCR
  1081  VSVGPLDQVW VIANKVQGSH SLSRGTVCHR TGVQPHEPKG HGWDYGIGGG WDHISVRANA
  1141  TRAPRSSSQE QEPSAPPEAH GPVCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TECPR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 18 nTPM
cerebral cortex: 17 nTPM
spleen: 17 nTPM
pituitary gland: 16 nTPM
cerebellum: 13 nTPM
hippocampal formation: 13 nTPM

Single-cell type

rod photoreceptor cells: 83 nCPM
salivary acinar cells: 71 nCPM
cone photoreceptor cells: 66 nCPM
neutrophils: 50 nCPM
retinal bipolar cells: 44 nCPM
adrenal medulla cells: 43 nCPM

Immune cell

naive CD4 T-cell: 4.9 nTPM
non-classical monocyte: 4.9 nTPM
naive CD8 T-cell: 4.2 nTPM
neutrophil: 3.4 nTPM
intermediate monocyte: 3.2 nTPM
T-reg: 3 nTPM

Brain region

pons: 31 nTPM
hypothalamus: 31 nTPM
hippocampal formation: 30 nTPM
cerebral cortex: 29 nTPM
medulla oblongata: 28 nTPM
midbrain: 28 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TECPR1.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 258 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0
gnomAD missense Z: 1.86
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

phosphatidylinositol-3-phosphate binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Peroxin/Ferlin domain
Beta-propeller repeat TECPR
PH-like domain superfamily
Propeller
Tectonin domain
TECPR1-like, DysF domain
Tectonin beta-propeller repeat-containing
Integral peroxisomal membrane peroxin

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TECPR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TECPR1 as an antibody target. Whether an autoantibody or antibody against TECPR1 could matter depends on whether native TECPR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TECPR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TECPR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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