Seroatlas · Human Serome Atlas

ZC3H4

Zinc finger CCCH domain-containing protein 4

Also known as: C19orf7, KIAA1064, ZC3H4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UPT8
Gene
ZC3H4
Ensembl
ENSG00000130749
Chromosome
19
Canonical length
1303 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of a family of CCCH (C-x8-C-x5-C-x3-H type) zinc finger domain-containing proteins. These zinc finger domains, which coordinate zinc finger binding and are characterized by three cysteine residues and one histidine residue, are nucleic acid-binding. Other family members are known to function in post-transcriptional regulation. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

1303 residues, UniProt reviewed canonical sequence.

>Q9UPT8|ZC3H4
     1  MEAAPGTPPP PPSESPPPPS PPPPSTPSPP PCSPDARPAT PHLLHHRLPL PDDREDGELE
    61  EGELEDDGAE ETQDTSGGPE RSRKEKGEKH HSDSDEEKSH RRLKRKRKKE REKEKRRSKK
   121  RRKSKHKRHA SSSDDFSDFS DDSDFSPSEK GHRKYREYSP PYAPSHQQYP PSHATPLPKK
   181  AYSKMDSKSY GMYEDYENEQ YGEYEGDEEE DMGKEDYDDF TKELNQYRRA KEGSSRGRGS
   241  RGRGRGYRGR GSRGGSRGRG MGRGSRGRGR GSMGGDHPED EEDFYEEEMD YGESEEPMGD
   301  DDYDEYSKEL NQYRRSKDSR GRGLSRGRGR GSRGRGKGMG RGRGRGGSRG GMNKGGMNDD
   361  EDFYDEDMGD GGGGSYRSRD HDKPHQQSDK KGKVICKYFV EGRCTWGDHC NFSHDIELPK
   421  KRELCKFYIT GFCARAENCP YMHGDFPCKL YHTTGNCING DDCMFSHDPL TEETRELLDK
   481  MLADDAEAGA EDEKEVEELK KQGINPLPKP PPGVGLLPTP PRPPGPQAPT SPNGRPMQGG
   541  PPPPPPPPPP PPGPPQMPMP VHEPLSPQQL QQQDMYNKKI PSLFEIVVRP TGQLAEKLGV
   601  RFPGPGGPPG PMGPGPNMGP PGPMGGPMHP DMHPDMHPDM HPDMHADMHA DMPMGPGMNP
   661  GPPMGPGGPP MMPYGPGDSP HSGMMPPIPP AQNFYENFYQ QQEGMEMEPG LLGDAEDYGH
   721  YEELPGEPGE HLFPEHPLEP DSFSEGGPPG RPKPGAGVPD FLPSAQRALY LRIQQKQQEE
   781  EERARRLAES SKQDRENEEG DTGNWYSSDE DEGGSSVTSI LKTLRQQTSS RPPASVGELS
   841  SSGLGDPRLQ KGHPTGSRLA DPRLSRDPRL TRHVEASGGS GPGDSGPSDP RLARALPTSK
   901  PEGSLHSSPV GPSSSKGSGP PPTEEEEGER ALREKAVNIP LDPLPGHPLR DPRSQLQQFS
   961  HIKKDVTLSK PSFARTVLWN PEDLIPLPIP KQDAVPPVPA ALQSMPTLDP RLHRAATAGP
  1021  PNARQRPGAS TDSSTQGANL PDFELLSRIL KTVNATGSSA APGSSDKPSD PRVRKAPTDP
  1081  RLQKPTDSTA SSRAAKPGPA EAPSPTASPS GDASPPATAP YDPRVLAAGG LGQGGGGGQS
  1141  SVLSGISLYD PRTPNAGGKA TEPAADTGAQ PKGAEGNGKS SASKAKEPPF VRKSALEQPE
  1201  TGKAGADGGT PTDRYNSYNR PRPKAAAAPA ATTATPPPEG APPQPGVHNL PVPTLFGTVK
  1261  QTPKTGSGSP FAGNSPAREG EQDAASLKDV FKGFDPTASP FCQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC3H4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 14 nTPM
  • spleen: 12 nTPM
  • endometrium: 11 nTPM
  • esophagus: 11 nTPM
  • testis: 11 nTPM
  • pancreas: 10 nTPM

Single-cell type

  • neutrophils: 99 nCPM
  • epicardial cells: 89 nCPM
  • monocyte progenitors: 71 nCPM
  • neutrophil progenitors: 68 nCPM
  • ocular epithelial cells: 63 nCPM
  • megakaryocyte progenitors: 56 nCPM

Immune cell

  • plasmacytoid DC: 3 nTPM
  • neutrophil: 2.7 nTPM
  • basophil: 2.6 nTPM
  • MAIT T-cell: 2.3 nTPM
  • memory CD8 T-cell: 2.3 nTPM
  • NK-cell: 2.3 nTPM

Brain region

  • cerebellum: 32 nTPM
  • medulla oblongata: 32 nTPM
  • amygdala: 32 nTPM
  • basal ganglia: 31 nTPM
  • thalamus: 31 nTPM
  • midbrain: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.05
gnomAD pLI
1
gnomAD missense Z
0.66
DepMap mean gene effect
-0.16
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZC3H4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC3H4 as an antibody target. Whether an autoantibody or antibody against ZC3H4 could matter depends on whether native ZC3H4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC3H4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC3H4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZC3H4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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