Seroatlas · Human Serome Atlas

WDR75

WD repeat-containing protein 75

Also known as: FLJ12519, NET16, UTP17, WDR75_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWA0
Gene: WDR75
Ensembl: ENSG00000115368
Chromosome: 2
Canonical length: 830 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables RNA binding activity. Involved in positive regulation of rRNA processing; positive regulation of transcription by RNA polymerase I; and ribosomal small subunit biogenesis. Located in nucleolus. Part of small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

830 residues, UniProt reviewed canonical sequence.

>Q8IWA0|WDR75
     1  MVEEENIRVV RCGGSELNFR RAVFSADSKY IFCVSGDFVK VYSTVTEECV HILHGHRNLV
    61  TGIQLNPNNH LQLYSCSLDG TIKLWDYIDG ILIKTFIVGC KLHALFTLAQ AEDSVFVIVN
   121  KEKPDIFQLV SVKLPKSSSQ EVEAKELSFV LDYINQSPKC IAFGNEGVYV AAVREFYLSV
   181  YFFKKKTTSR FTLSSSRNKK HAKNNFTCVA CHPTEDCIAS GHMDGKIRLW RNFYDDKKYT
   241  YTCLHWHHDM VMDLAFSVTG TSLLSGGRES VLVEWRDATE KNKEFLPRLG ATIEHISVSP
   301  AGDLFCTSHS DNKIIIIHRN LEASAVIQGL VKDRSIFTGL MIDPRTKALV LNGKPGHLQF
   361  YSLQSDKQLY NLDIIQQEYI NDYGLIQIEL TKAAFGCFGN WLATVEQRQE KETELELQMK
   421  LWMYNKKTQG FILNTKINMP HEDCITALCF CNAEKSEQPT LVTASKDGYF KVWILTDDSD
   481  IYKKAVGWTC DFVGSYHKYQ ATNCCFSEDG SLLAVSFEEI VTIWDSVTWE LKCTFCQRAG
   541  KIRHLCFGRL TCSKYLLGAT ENGILCCWNL LSCALEWNAK LNVRVMEPDP NSENIAAISQ
   601  SSVGSDLFVF KPSEPRPLYI QKGISREKVQ WGVFVPRDVP ESFTSEAYQW LNRSQFYFLT
   661  KSQSLLTFST KSPEEKLTPT SKQLLAEESL PTTPFYFILG KHRQQQDEKL NETLENELVQ
   721  LPLTENIPAI SELLHTPAHV LPSAAFLCSM FVNSLLLSKE TKSAKEIPED VDMEEEKESE
   781  DSDEENDFTE KVQDTSNTGL GEDIIHQLSK SEEKELRKFR KIDYSWIAAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR75 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

lymph node: 25 nTPM
cervix: 24 nTPM
ovary: 23 nTPM
breast: 23 nTPM
tonsil: 23 nTPM
epididymis: 22 nTPM

Single-cell type

kupffer cells: 130 nCPM
myonuclei: 93 nCPM
erythrocyte progenitors: 74 nCPM
megakaryocyte-erythroid progenitors: 69 nCPM
adrenal cortex cells: 58 nCPM
leydig cells: 53 nCPM

Immune cell

MAIT T-cell: 11 nTPM
T-reg: 8.4 nTPM
myeloid DC: 8 nTPM
naive CD4 T-cell: 7.7 nTPM
NK-cell: 7.6 nTPM
naive CD8 T-cell: 7.5 nTPM

Brain region

white matter: 23 nTPM
cerebral cortex: 22 nTPM
cerebellum: 21 nTPM
spinal cord: 21 nTPM
medulla oblongata: 20 nTPM
pons: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0
gnomAD missense Z: 1.21
DepMap mean gene effect: -1.57
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
Quinoprotein alcohol dehydrogenase-like superfamily
WD40/YVTN repeat-like-containing domain superfamily
WD repeat-containing protein 75
WD repeat-containing protein 75, second beta-propeller
WD repeat-containing protein 75 second beta-propeller
WD repeat-containing protein 75 first beta-propeller

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR75 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR75 as an antibody target. Whether an autoantibody or antibody against WDR75 could matter depends on whether native WDR75 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR75 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR75 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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