Seroatlas · Human Serome Atlas

NOL11

Nucleolar protein 11

Also known as: DKFZP586L0724, NOL11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H8H0
Gene: NOL11
Ensembl: ENSG00000130935
Chromosome: 17
Canonical length: 719 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

Enables RNA binding activity. Involved in maturation of SSU-rRNA and positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Located in nucleolus. Part of t-UTP complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

719 residues, UniProt reviewed canonical sequence.

>Q9H8H0|NOL11
     1  MAALEEEFTL SSVVLSAGPE GLLGVEQSDK TDQFLVTDSG RTVILYKVSD QKPLGSWSVK
    61  QGQIITCPAV CNFQTGEYVV VHDNKVLRIW NNEDVNLDKV FKATLSAEVY RILSVQGTEP
   121  LVLFKEGAVR GLEALLADPQ QKIETVISDE EVIKWTKFFV VFRHPVLIFI TEKHGNYFAY
   181  VQMFNSRILT KYTLLLGQDE NSVIKSFTAS VDRKFISLMS LSSDGCIYET LIPIRPADPE
   241  KNQSLVKSLL LKAVVSGNAR NGVALTALDQ DHVAVLGSPL AASKECLSVW NIKFQTLQTS
   301  KELPQGTSGQ LWYYGEHLFM LHGKSLTVIP YKCEVSSLAG ALGKLKHSQD PGTHVVSHFV
   361  NWETPQGCGL GFQNSEQSRR ILRRRKIEVS LQPEVPPSKQ LLSTIMKDSE KHIEVEVRKF
   421  LALKQTPDFH TVIGDTVTGL LERCKAEPSF YPRNCLMQLI QTHVLSYSLC PDLMEIALKK
   481  KDVQLLQLCL QQFPDIPESV TCACLKIFLS IGDDSLQETD VNMESVFDYS INSVHDEKME
   541  EQTEILQNGF NPEEDKCNNC DQELNKKPQD ETKESTSCPV VQKRAALLNA ILHSAYSETF
   601  LLPHLKDIPA QHITLFLKYL YFLYLKCSEN ATMTLPGIHP PTLNQIMDWI CLLLDANFTV
   661  VVMMPEAKRL LINLYKLVKS QISVYSELNK IEVSFRELQK LNQEKNNRGL YSIEVLELF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOL11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

tonsil: 23 nTPM
lymph node: 21 nTPM
bone marrow: 20 nTPM
thymus: 18 nTPM
liver: 18 nTPM
urinary bladder: 17 nTPM

Single-cell type

erythrocyte progenitors: 63 nCPM
megakaryocyte progenitors: 62 nCPM
cytotrophoblasts: 57 nCPM
migrating cytotrophoblasts: 55 nCPM
megakaryocyte-erythroid progenitors: 53 nCPM
extravillous trophoblasts: 47 nCPM

Immune cell

naive CD4 T-cell: 16 nTPM
NK-cell: 13 nTPM
naive B-cell: 13 nTPM
basophil: 13 nTPM
naive CD8 T-cell: 12 nTPM
memory CD8 T-cell: 12 nTPM

Brain region

cerebellum: 21 nTPM
white matter: 19 nTPM
choroid plexus: 14 nTPM
thalamus: 13 nTPM
cerebral cortex: 13 nTPM
medulla oblongata: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0
gnomAD missense Z: 0.42
DepMap mean gene effect: -0.69
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40-repeat-containing domain superfamily
Nucleolar protein 11, N-terminal domain
Nucleolar protein 11
Nucleolar protein 11, C-terminal domain
Nucleolar protein 11 N-terminal domain
Nucleolar protein 11 C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NOL11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOL11 as an antibody target. Whether an autoantibody or antibody against NOL11 could matter depends on whether native NOL11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOL11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NOL11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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