Seroatlas · Human Serome Atlas

UTP15

U3 small nucleolar RNA-associated protein 15 homolog

Also known as: FLJ12787, FLJ23637, NET21, UTP15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TED0
Gene: UTP15
Ensembl: ENSG00000164338
Chromosome: 5
Canonical length: 518 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Endoplasmic reticulum

OverviewNCBI Gene

Enables RNA binding activity. Involved in positive regulation of rRNA processing; positive regulation of transcription by RNA polymerase I; and ribosomal small subunit biogenesis. Located in endoplasmic reticulum and fibrillar center. Part of small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

518 residues, UniProt reviewed canonical sequence.

>Q8TED0|UTP15
     1  MAGYKPVAIQ TYPILGEKIT QDTLYWNNYK TPVQIKEFGA VSKVDFSPQP PYNYAVTASS
    61  RIHIYGRYSQ EPIKTFSRFK DTAYCATFRQ DGRLLVAGSE DGGVQLFDIS GRAPLRQFEG
   121  HTKAVHTVDF TADKYHVVSG ADDYTVKLWD IPNSKEILTF KEHSDYVRCG CASKLNPDLF
   181  ITGSYDHTVK MFDARTSESV LSVEHGQPVE SVLLFPSGGL LVSAGGRYVK VWDMLKGGQL
   241  LVSLKNHHKT VTCLCLSSSG QRLLSGSLDR KVKVYSTTSY KVVHSFDYAA SILSLALAHE
   301  DETIVVGMTN GILSVKHRKS EAKKESLPRR RRPAYRTFIK GKNYMKQRDD ILINRPAKKH
   361  LELYDRDLKH FRISKALDRV LDPTCTIKTP EITVSIIKEL NRRGVLANAL AGRDEKEISH
   421  VLNFLIRNLS QPRFAPVLIN AAEIIIDIYL PVIGQSPVVD KKFLLLQGLV EKEIDYQREL
   481  LETLGMMDML FATMRRKEGT SVLEHTSDGF PENKKIES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UTP15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 35 nTPM
tonsil: 10 nTPM
lymph node: 10 nTPM
breast: 9.1 nTPM
skin: 8.9 nTPM
esophagus: 8.7 nTPM

Single-cell type

cardiomyocytes: 54 nCPM
erythrocyte progenitors: 21 nCPM
basal keratinocytes: 18 nCPM
differentiating spermatogonia: 18 nCPM
suprabasal keratinocytes: 17 nCPM
ocular epithelial cells: 17 nCPM

Immune cell

naive CD4 T-cell: 9.7 nTPM
naive CD8 T-cell: 9.4 nTPM
memory CD8 T-cell: 9.1 nTPM
gdT-cell: 8.2 nTPM
NK-cell: 8.2 nTPM
memory CD4 T-cell: 8.1 nTPM

Brain region

white matter: 13 nTPM
cerebral cortex: 12 nTPM
cerebellum: 12 nTPM
pons: 11 nTPM
midbrain: 11 nTPM
hypothalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.11
gnomAD pLI: 1
gnomAD missense Z: 1.44
DepMap mean gene effect: -1.66
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
WD40/YVTN repeat-like-containing domain superfamily
WD40 repeat, conserved site
WD40-repeat-containing domain superfamily
WD domain, G-beta repeat
U3 small nucleolar RNA-associated protein 15, C-terminal
UTP15 C terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UTP15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UTP15 as an antibody target. Whether an autoantibody or antibody against UTP15 could matter depends on whether native UTP15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UTP15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UTP15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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