Seroatlas · Human Serome Atlas

UQCRC1

Cytochrome b-c1 complex subunit 1, mitochondrial

Also known as: D3S3191, QCR1, QCR1_HUMAN, UQCR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P31930
Gene
UQCRC1
Ensembl
ENSG00000010256
Chromosome
3
Canonical length
480 aa
Protein class
Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Enables ubiquitin protein ligase binding activity. Predicted to be involved in oxidative phosphorylation. Predicted to act upstream of or within mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrial inner membrane. Implicated in Alzheimer's disease. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

480 residues, UniProt reviewed canonical sequence.

>P31930|UQCRC1
     1  MAASVVCRAA TAGAQVLLRA RRSPALLRTP ALRSTATFAQ ALQFVPETQV SLLDNGLRVA
    61  SEQSSQPTCT VGVWIDVGSR FETEKNNGAG YFLEHLAFKG TKNRPGSALE KEVESMGAHL
   121  NAYSTREHTA YYIKALSKDL PKAVELLGDI VQNCSLEDSQ IEKERDVILR EMQENDASMR
   181  DVVFNYLHAT AFQGTPLAQA VEGPSENVRK LSRADLTEYL STHYKAPRMV LAAAGGVEHQ
   241  QLLDLAQKHL GGIPWTYAED AVPTLTPCRF TGSEIRHRDD ALPFAHVAIA VEGPGWASPD
   301  NVALQVANAI IGHYDCTYGG GVHLSSPLAS GAVANKLCQS FQTFSICYAE TGLLGAHFVC
   361  DRMKIDDMMF VLQGQWMRLC TSATESEVAR GKNILRNALV SHLDGTTPVC EDIGRSLLTY
   421  GRRIPLAEWE SRIAEVDASV VREICSKYIY DQCPAVAGYG PIEQLPDYNR IRSGMFWLRF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UQCRC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
826 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 826 nTPM
  • skeletal muscle: 718 nTPM
  • heart muscle: 605 nTPM
  • choroid plexus: 254 nTPM
  • liver: 188 nTPM
  • parathyroid gland: 181 nTPM

Single-cell type

  • parietal cells: 601 nCPM
  • colonocytes: 546 nCPM
  • late spermatids: 538 nCPM
  • enterocytes: 497 nCPM
  • esophageal basal cells: 469 nCPM
  • syncytiotrophoblasts: 396 nCPM

Immune cell

  • total PBMC: 987 nTPM
  • intermediate monocyte: 666 nTPM
  • classical monocyte: 645 nTPM
  • non-classical monocyte: 611 nTPM
  • myeloid DC: 594 nTPM
  • eosinophil: 326 nTPM

Brain region

  • choroid plexus: 158 nTPM
  • cerebellum: 136 nTPM
  • hypothalamus: 131 nTPM
  • pons: 129 nTPM
  • medulla oblongata: 123 nTPM
  • thalamus: 123 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UQCRC1.

Disease | AllUniProt

Conditions UQCRC1 is implicated in, by any mechanism.

  • Parkinsonism with polyneuropathy (PKNPY) MIM:619279

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 112 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.02
gnomAD missense Z
0.56
DepMap mean gene effect
-0.5
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UQCRC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UQCRC1 as an antibody target. Whether an autoantibody or antibody against UQCRC1 could matter depends on whether native UQCRC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UQCRC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UQCRC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UQCRC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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