Seroatlas · Human Serome Atlas

UQCC6

Ubiquinol-cytochrome c reductase complex assembly factor 6

Also known as: BRAWNIN, C12orf73, DKFZp547P055, FLJ13975, UQCC6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q69YU5
Gene: UQCC6
Ensembl: ENSG00000204954
Chromosome: 12
Canonical length: 71 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Centrosome,Mitochondria
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Involved in mitochondrial cytochrome c oxidase assembly and mitochondrial respiratory chain complex III assembly. Located in mitochondrion. Is active in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

71 residues, UniProt reviewed canonical sequence.

>Q69YU5|UQCC6
     1  MPAGVPMSTY LKMFAASLLA MCAGAEVVHR YYRPDLTIPE IPPKRGELKT ELLGLKERKH
    61  KPQVSQQEEL K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UQCC6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 40 nTPM
tongue: 26 nTPM
spinal cord: 14 nTPM
hypothalamus: 13 nTPM
cerebral cortex: 13 nTPM
amygdala: 13 nTPM

Single-cell type

epicardial cells: 735 nCPM
early spermatids: 118 nCPM
plasma cells: 113 nCPM
cardiomyocytes: 67 nCPM
megakaryocytes: 56 nCPM
mesothelial cells: 51 nCPM

Immune cell

T-reg: 17 nTPM
naive CD4 T-cell: 16 nTPM
naive CD8 T-cell: 15 nTPM
memory B-cell: 15 nTPM
NK-cell: 15 nTPM
plasmacytoid DC: 13 nTPM

Brain region

white matter: 21 nTPM
cerebellum: 21 nTPM
hypothalamus: 21 nTPM
basal ganglia: 18 nTPM
cerebral cortex: 18 nTPM
pons: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0.02
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein BRAWNIN
Domain of unknown function (DUF4516)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UQCC6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UQCC6 as an antibody target. Whether an autoantibody or antibody against UQCC6 could matter depends on whether native UQCC6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UQCC6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UQCC6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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