UQCRQ

Protein identityUniProt · HPA

UniProt accession

O14949

Gene

UQCRQ

Ensembl

ENSG00000164405

Chromosome

5

Canonical length

82 aa

Protein class

Disease related genes, Human disease related genes, Metabolic proteins, Predicted membrane proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

82 residues, UniProt reviewed canonical sequence.

>O14949|UQCRQ
     1  MGREFGNLTR MRHVISYSLS PFEQRAYPHV FTKGIPNVLR RIRESFFRVV PQFVVFYLIY
    61  TWGTEEFERS KRKNPAAYEN DK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UQCRQ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.56

Highest tissue expression

1,218 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UQCRQ.

Disease | AllUniProt

Conditions UQCRQ is implicated in, by any mechanism.

• Mitochondrial complex III deficiency, nuclear type 4 (MC3DN4) MIM:615159

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.69

gnomAD pLI

0.05

gnomAD missense Z

0.42

DepMap mean gene effect

-0.42

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular respiration
• cerebellar Purkinje cell layer development
• hippocampus development
• hypothalamus development
• midbrain development
• mitochondrial electron transport, ubiquinol to cytochrome c
• pyramidal neuron development
• thalamus development
• pons development
• subthalamus development

Cellular components

• mitochondrial inner membrane
• mitochondrion
• respiratory chain complex III

Protein domainsUniProt · Pfam · InterPro

• Cytochrome b-c1 complex subunit 8
• Cytochrome b-c1 complex subunit 8 superfamily
• UcrQ family

KeywordsUniProt

• Acetylation
• Electron transport
• Membrane
• Mitochondrion
• Mitochondrion inner membrane
• Phosphoprotein
• Primary mitochondrial disease
• Respiratory chain
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of UQCRQ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• UQCC6
• UQCRC1