Seroatlas · Human Serome Atlas

STMP1

Short transmembrane mitochondrial protein 1

Also known as: C7orf73, Mm47, PL-5283, STMP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: E0CX11
Gene: STMP1
Ensembl: ENSG00000243317
Chromosome: 7
Canonical length: 47 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Involved in mitochondrial cytochrome c oxidase assembly and mitochondrial respirasome assembly. Located in mitochondrion. Is active in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

47 residues, UniProt reviewed canonical sequence.

>E0CX11|STMP1
     1  MLQFLLGFTL GNVVGMYLAQ NYDIPNLAKK LEEIKKDLDA KKKPPSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STMP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 45 nTPM
esophagus: 45 nTPM
bone marrow: 39 nTPM
tongue: 31 nTPM
thyroid gland: 30 nTPM
liver: 30 nTPM

Single-cell type

esophageal apical cells: 2,119 nCPM
late spermatids: 1,998 nCPM
esophageal suprabasal cells: 740 nCPM
platelets: 569 nCPM
syncytiotrophoblasts: 491 nCPM
late primary spermatocytes: 418 nCPM

Immune cell

basophil: 433 nTPM
eosinophil: 128 nTPM
non-classical monocyte: 68 nTPM
intermediate monocyte: 61 nTPM
myeloid DC: 61 nTPM
classical monocyte: 57 nTPM

Brain region

medulla oblongata: 26 nTPM
choroid plexus: 26 nTPM
hypothalamus: 25 nTPM
white matter: 24 nTPM
basal ganglia: 24 nTPM
spinal cord: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0.55
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Short transmembrane mitochondrial protein 1
Domain of unknown function (DUF4535)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STMP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STMP1 as an antibody target. Whether an autoantibody or antibody against STMP1 could matter depends on whether native STMP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STMP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STMP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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