Peptidase M16, N-terminal
IPR011765
Definition
This entry represents an N-terminal domain found in metallopeptidases and non-peptidase homologues belonging to MEROPS peptidase family M16 (clan ME), subfamilies M16A, M16B and M16C. Members of this group of proteins include: Insulinase, insulin-degrading enzyme ([ec:3.4.24.56]) Mitochondrial processing peptidase alpha subunit, (Alpha-MPP, [ec:3.4.24.64]) Pitrilysin, Protease III precursor ([ec:3.4.24.55]) Nardilysin ([ec:3.4.24.61]) Ubiquinol-cytochrome C reductase complex core protein I,mitochondrial precursor ([ec:1.10.2.2]) Coenzyme PQQ synthesis protein F ([ec:3.4.99]) These proteins do not share many regions of sequence similarity; the most noticeable is in the N-terminal section. This region includes a conserved histidine followed, two residues later by a glutamate and another histidine. In pitrilysin, it has been shown PMID:7990931 that this H-x-x-E-H motif is involved in enzymatic activity; the two histidines bind zinc and the glutamate is necessary for catalytic activity. The proteins classified as non-peptidase homologues either have been found experimentally to be without peptidase activity, or lack amino acid residues that are believed to be essential for the catalytic activity.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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