Seroatlas · Human Serome Atlas

UBE2Z

Ubiquitin-conjugating enzyme E2 Z

Also known as: FLJ13855, UBE2Z_HUMAN, USE1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H832
Gene: UBE2Z
Ensembl: ENSG00000159202
Chromosome: 17
Canonical length: 354 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

354 residues, UniProt reviewed canonical sequence.

>Q9H832|UBE2Z
     1  MAESPTEEAA TAGAGAAGPG ASSVAGVVGV SGSGGGFGPP FLPDVWAAAA AAGGAGGPGS
    61  GLAPLPGLPP SAAAHGAALL SHWDPTLSSD WDGERTAPQC LLRIKRDIMS IYKEPPPGMF
   121  VVPDTVDMTK IHALITGPFD TPYEGGFFLF VFRCPPDYPI HPPRVKLMTT GNNTVRFNPN
   181  FYRNGKVCLS ILGTWTGPAW SPAQSISSVL ISIQSLMTEN PYHNEPGFEQ ERHPGDSKNY
   241  NECIRHETIR VAVCDMMEGK CPCPEPLRGV MEKSFLEYYD FYEVACKDRL HLQGQTMQDP
   301  FGEKRGHFDY QSLLMRLGLI RQKVLERLHN ENAEMDSDSS SSGTETDLHG SLRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2Z can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

epididymis: 57 nTPM
tonsil: 56 nTPM
thyroid gland: 47 nTPM
smooth muscle: 46 nTPM
adrenal gland: 45 nTPM
esophagus: 44 nTPM

Single-cell type

epididymal principal cells: 97 nCPM
epididymal clear cells: 92 nCPM
ocular epithelial cells: 91 nCPM
pancreatic duct cells: 89 nCPM
endometrial glandular cells: 84 nCPM
oligodendrocytes: 82 nCPM

Immune cell

intermediate monocyte: 9.9 nTPM
non-classical monocyte: 9.5 nTPM
naive B-cell: 8.6 nTPM
memory CD8 T-cell: 8.4 nTPM
gdT-cell: 8.3 nTPM
T-reg: 8.2 nTPM

Brain region

white matter: 106 nTPM
cerebral cortex: 81 nTPM
pons: 78 nTPM
thalamus: 74 nTPM
hypothalamus: 74 nTPM
basal ganglia: 72 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.36
gnomAD pLI: 0.94
gnomAD missense Z: 2.87
DepMap mean gene effect: -0.36
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2Z in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2Z as an antibody target. Whether an autoantibody or antibody against UBE2Z could matter depends on whether native UBE2Z is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2Z is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2Z as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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