APIP

Protein identityUniProt · HPA

UniProt accession

Q96GX9

Gene

APIP

Ensembl

ENSG00000149089

Chromosome

11

Canonical length

242 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

Quaternary structure

Homotetramer

OverviewNCBI Gene

Enables identical protein binding activity; methylthioribulose 1-phosphate dehydratase activity; and zinc ion binding activity. Involved in several processes, including L-methionine salvage from methylthioadenosine; protein homotetramerization; and pyroptotic inflammatory response. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

242 residues, UniProt reviewed canonical sequence.

>Q96GX9|APIP
     1  MSGCDAREGD CCSRRCGAQD KEHPRYLIPE LCKQFYHLGW VTGTGGGISL KHGDEIYIAP
    61  SGVQKERIQP EDMFVCDINE KDISGPSPSK KLKKSQCTPL FMNAYTMRGA GAVIHTHSKA
   121  AVMATLLFPG REFKITHQEM IKGIKKCTSG GYYRYDDMLV VPIIENTPEE KDLKDRMAHA
   181  MNEYPDSCAV LVRRHGVYVW GETWEKAKTM CECYDYLFDI AVSMKKVGLD PSQLPVGENG
   241  IV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

62 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.74

gnomAD pLI

0

gnomAD missense Z

0.79

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• L-methionine salvage from methylthioadenosine
• negative regulation of apoptotic process
• protein homotetramerization
• pyroptotic inflammatory response
• regulation of ERK1 and ERK2 cascade

Molecular functions

• identical protein binding
• zinc ion binding
• methylthioribulose 1-phosphate dehydratase activity

Cellular components

• cytoplasm
• cytosol

Protein domainsUniProt · Pfam · InterPro

• Class II aldolase/adducin N-terminal
• Class II aldolase/adducin N-terminal domain superfamily
• Class II Aldolase and Adducin N-terminal domain
• Methylthioribulose-1-phosphate dehydratase
• Methylthioribulose-1-phosphate dehydratase, eukaryotes

KeywordsUniProt

• Amino-acid biosynthesis
• Apoptosis
• Cytoplasm
• Lyase
• Metal-binding
• Methionine biosynthesis
• Phosphoprotein
• Zinc

InteractionsUniProt · HPA

Protein binding partners of APIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• APAF1
• TSC22D4