Seroatlas · Human Serome Atlas

NRBP2

Nuclear receptor-binding protein 2

Also known as: DKFZp434P086, NRBP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NSY0
Gene: NRBP2
Ensembl: ENSG00000185189
Chromosome: 8
Canonical length: 501 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable protein serine/threonine kinase activity. Involved in negative regulation of macroautophagy. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

501 residues, UniProt reviewed canonical sequence.

>Q9NSY0|NRBP2
     1  MAAPEPAPRR ARERERERED ESEDESDILE ESPCGRWQKR REQVNQGNMP GLQSTFLAMD
    61  TEEGVEVVWN ELHFGDRKAF AAHEEKIQTV FEQLVLVDHP NIVKLHKYWL DTSEACARVI
   121  FITEYVSSGS LKQFLKKTKK NHKAMNARAW KRWCTQILSA LSFLHACSPP IIHGNLTSDT
   181  IFIQHNGLIK IGSVWHRIFS NALPDDLRSP IRAEREELRN LHFFPPEYGE VADGTAVDIF
   241  SFGMCALEMA VLEIQTNGDT RVTEEAIARA RHSLSDPNMR EFILCCLARD PARRPSAHSL
   301  LFHRVLFEVH SLKLLAAHCF IQHQYLMPEN VVEEKTKAMD LHAVLAELPR PRRPPLQWRY
   361  SEVSFMELDK FLEDVRNGIY PLMNFAATRP LGLPRVLAPP PEEVQKAKTP TPEPFDSETR
   421  KVIQMQCNLE RSEDKARWHL TLLLVLEDRL HRQLTYDLLP TDSAQDLASE LVHYGFLHED
   481  DRMKLAAFLE STFLKYRGTQ A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NRBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 95 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 95 nTPM
midbrain: 42 nTPM
hippocampal formation: 33 nTPM
liver: 33 nTPM
cerebral cortex: 29 nTPM
amygdala: 28 nTPM

Single-cell type

astrocytes: 91 nCPM
ependymal cells: 84 nCPM
bergmann glia: 57 nCPM
oligodendrocytes: 57 nCPM
tuft cells: 46 nCPM
pituicytes/fscs: 37 nCPM

Immune cell

MAIT T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

medulla oblongata: 108 nTPM
white matter: 103 nTPM
pons: 83 nTPM
thalamus: 79 nTPM
cerebellum: 78 nTPM
midbrain: 78 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.02
gnomAD missense Z: 1.92
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Protein kinase domain
Protein kinase-like domain superfamily
With No Lysine (K) Ser/Thr Protein Kinase
Protein kinase domain
Nuclear receptor-binding protein 2, pseudokinase domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NRBP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NRBP2 as an antibody target. Whether an autoantibody or antibody against NRBP2 could matter depends on whether native NRBP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NRBP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NRBP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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