Seroatlas · Human Serome Atlas

CCDC90B

Coiled-coil domain-containing protein 90B, mitochondrial

Also known as: CC90B_HUMAN, MDS011, MDS025

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZT6
Gene: CCDC90B
Ensembl: ENSG00000137500
Chromosome: 11
Canonical length: 254 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

254 residues, UniProt reviewed canonical sequence.

>Q9GZT6|CCDC90B
     1  MNSRQAWRLF LSQGRGDRWV SRPRGHFSPA LRREFFTTTT KEGYDRRPVD ITPLEQRKLT
    61  FDTHALVQDL ETHGFDKTQA ETIVSALTAL SNVSLDTIYK EMVTQAQQEI TVQQLMAHLD
   121  AIRKDMVILE KSEFANLRAE NEKMKIELDQ VKQQLMHETS RIRADNKLDI NLERSRVTDM
   181  FTDQEKQLME TTTEFTKKDT QTKSIISETS NKIDAEIASL KTLMESNKLE TIRYLAASVF
   241  TCLAIALGFY RFWK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC90B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

testis: 38 nTPM
epididymis: 28 nTPM
liver: 28 nTPM
spinal cord: 26 nTPM
adrenal gland: 26 nTPM
midbrain: 20 nTPM

Single-cell type

late primary spermatocytes: 510 nCPM
early spermatids: 453 nCPM
late spermatids: 306 nCPM
esophageal apical cells: 266 nCPM
early primary spermatocytes: 245 nCPM
esophageal suprabasal cells: 99 nCPM

Immune cell

basophil: 70 nTPM
eosinophil: 50 nTPM
NK-cell: 36 nTPM
non-classical monocyte: 31 nTPM
intermediate monocyte: 28 nTPM
T-reg: 27 nTPM

Brain region

hypothalamus: 11 nTPM
white matter: 10 nTPM
midbrain: 8.9 nTPM
choroid plexus: 8.7 nTPM
medulla oblongata: 8.6 nTPM
spinal cord: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
gnomAD missense Z: 0
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC90B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC90B as an antibody target. Whether an autoantibody or antibody against CCDC90B could matter depends on whether native CCDC90B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC90B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC90B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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