TRPM7

Protein identityUniProt · HPA

UniProt accession

Q96QT4

Gene

TRPM7

Ensembl

ENSG00000092439

Chromosome

15

Canonical length

1865 aa

Protein class

Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels

Subcellular location

Nucleoplasm,Vesicles,Plasma membrane,Cytosol

Quaternary structure

Homotetramer

OverviewNCBI Gene

This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

1865 residues, UniProt reviewed canonical sequence.

>Q96QT4|TRPM7
     1  MSQKSWIEST LTKRECVYII PSSKDPHRCL PGCQICQQLV RCFCGRLVKQ HACFTASLAM
    61  KYSDVKLGDH FNQAIEEWSV EKHTEQSPTD AYGVINFQGG SHSYRAKYVR LSYDTKPEVI
   121  LQLLLKEWQM ELPKLVISVH GGMQKFELHP RIKQLLGKGL IKAAVTTGAW ILTGGVNTGV
   181  AKHVGDALKE HASRSSRKIC TIGIAPWGVI ENRNDLVGRD VVAPYQTLLN PLSKLNVLNN
   241  LHSHFILVDD GTVGKYGAEV RLRRELEKTI NQQRIHARIG QGVPVVALIF EGGPNVILTV
   301  LEYLQESPPV PVVVCEGTGR AADLLAYIHK QTEEGGNLPD AAEPDIISTI KKTFNFGQNE
   361  ALHLFQTLME CMKRKELITV FHIGSDEHQD IDVAILTALL KGTNASAFDQ LILTLAWDRV
   421  DIAKNHVFVY GQQWLVGSLE QAMLDALVMD RVAFVKLLIE NGVSMHKFLT IPRLEELYNT
   481  KQGPTNPMLF HLVRDVKQGN LPPGYKITLI DIGLVIEYLM GGTYRCTYTR KRFRLIYNSL
   541  GGNNRRSGRN TSSSTPQLRK SHESFGNRAD KKEKMRHNHF IKTAQPYRPK IDTVMEEGKK
   601  KRTKDEIVDI DDPETKRFPY PLNELLIWAC LMKRQVMARF LWQHGEESMA KALVACKIYR
   661  SMAYEAKQSD LVDDTSEELK QYSNDFGQLA VELLEQSFRQ DETMAMKLLT YELKNWSNST
   721  CLKLAVSSRL RPFVAHTCTQ MLLSDMWMGR LNMRKNSWYK VILSILVPPA ILLLEYKTKA
   781  EMSHIPQSQD AHQMTMDDSE NNFQNITEEI PMEVFKEVRI LDSNEGKNEM EIQMKSKKLP
   841  ITRKFYAFYH APIVKFWFNT LAYLGFLMLY TFVVLVQMEQ LPSVQEWIVI AYIFTYAIEK
   901  VREIFMSEAG KVNQKIKVWF SDYFNISDTI AIISFFIGFG LRFGAKWNFA NAYDNHVFVA
   961  GRLIYCLNII FWYVRLLDFL AVNQQAGPYV MMIGKMVANM FYIVVIMALV LLSFGVPRKA
  1021  ILYPHEAPSW TLAKDIVFHP YWMIFGEVYA YEIDVCANDS VIPQICGPGT WLTPFLQAVY
  1081  LFVQYIIMVN LLIAFFNNVY LQVKAISNIV WKYQRYHFIM AYHEKPVLPP PLIILSHIVS
  1141  LFCCICKRRK KDKTSDGPKL FLTEEDQKKL HDFEEQCVEM YFNEKDDKFH SGSEERIRVT
  1201  FERVEQMCIQ IKEVGDRVNY IKRSLQSLDS QIGHLQDLSA LTVDTLKTLT AQKASEASKV
  1261  HNEITRELSI SKHLAQNLID DGPVRPSVWK KHGVVNTLSS SLPQGDLESN NPFHCNILMK
  1321  DDKDPQCNIF GQDLPAVPQR KEFNFPEAGS SSGALFPSAV SPPELRQRLH GVELLKIFNK
  1381  NQKLGSSSTS IPHLSSPPTK FFVSTPSQPS CKSHLETGTK DQETVCSKAT EGDNTEFGAF
  1441  VGHRDSMDLQ RFKETSNKIK ILSNNNTSEN TLKRVSSLAG FTDCHRTSIP VHSKQAEKIS
  1501  RRPSTEDTHE VDSKAALIPD WLQDRPSNRE MPSEEGTLNG LTSPFKPAMD TNYYYSAVER
  1561  NNLMRLSQSI PFTPVPPRGE PVTVYRLEES SPNILNNSMS SWSQLGLCAK IEFLSKEEMG
  1621  GGLRRAVKVQ CTWSEHDILK SGHLYIIKSF LPEVVNTWSS IYKEDTVLHL CLREIQQQRA
  1681  AQKLTFAFNQ MKPKSIPYSP RFLEVFLLYC HSAGQWFAVE ECMTGEFRKY NNNNGDEIIP
  1741  TNTLEEIMLA FSHWTYEYTR GELLVLDLQG VGENLTDPSV IKAEEKRSCD MVFGPANLGE
  1801  DAIKNFRAKH HCNSCCRKLK LPDLKRNDYT PDKIIFPQDE PSDLNLQPGN STKESESTNS
  1861  VRLML

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRPM7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

6

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

103 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRPM7.

Disease | AllUniProt

Conditions TRPM7 is implicated in, by any mechanism.

• Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ALS-PDC1) MIM:105500

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 373 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Intestinal hypomagnesemia 1
• See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.56

gnomAD pLI

0

gnomAD missense Z

2.23

DepMap mean gene effect

-0.72

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• actomyosin structure organization
• calcium ion transmembrane transport
• calcium ion transport
• calcium-dependent cell-matrix adhesion
• intracellular magnesium ion homeostasis
• magnesium ion homeostasis
• magnesium ion transport
• monoatomic cation transmembrane transport
• necroptotic process
• protein autophosphorylation
• protein homotetramerization
• protein phosphorylation
• zinc ion transport

Molecular functions

• actin binding
• ATP binding
• calcium channel activity
• magnesium ion transmembrane transporter activity
• metal ion binding
• myosin binding
• protein kinase activity
• protein serine kinase activity
• protein serine/threonine kinase activity
• zinc ion transmembrane transporter activity

Cellular components

• cytoplasmic vesicle
• cytoplasmic vesicle membrane
• nucleus
• plasma membrane
• ruffle

Protein domainsUniProt · Pfam · InterPro

• Alpha-type protein kinase, alpha-kinase domain
• Protein kinase-like domain superfamily
• TRPM, tetramerisation domain
• TRPM, tetramerisation domain superfamily
• TRPM, SLOG domain
• Transient receptor potential cation channel M
• TRPM-like domain
• Alpha-kinase family
• Tetramerisation domain of TRPM
• SLOG in TRPM
• TRPM2-like domain
• Transient receptor potential cation channel subfamily M member 7, alpha-kinase domain

KeywordsUniProt

• Acetylation
• Amyotrophic lateral sclerosis
• ATP-binding
• Calcium
• Calcium channel
• Calcium transport
• Cell membrane
• Coiled coil
• Cytoplasmic vesicle
• Ion channel
• Ion transport
• Kinase
• Lipoprotein
• Membrane
• Metal-binding
• Necrosis
• Neurodegeneration
• Nucleotide-binding
• Nucleus
• Palmitate
• Parkinsonism
• Phosphoprotein
• Serine/threonine-protein kinase
• Transferase
• Transmembrane
• Transmembrane helix
• Transport
• Zinc

InteractionsUniProt · HPA

Protein binding partners of TRPM7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PLCB1
• ARL15