TRPM2-like domain
PF25508
Definition
This domain is found in human Transient receptor potential cation channel subfamily M member 2 (TRPM2) and similar proteins. TRPM2 is a nonselective, voltage-independent cation channel that mediates Na+ and Ca2+ influx, leading to increased cytoplasmic Ca2+ levels. It plays a role in mediating behavioural and physiological responses to moderate heat, insulin secretion, dendritic cell differentiation and maturation and the the regulation of the reorganisation of the actin cytoskeleton and filopodia formation. This domain is found associated with [pfam:PF00520] and adopts an all-alpha configuration.
8 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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