Alpha-type protein kinase, alpha-kinase domain

Definition

This entry represents a protein kinase catalytic domain with no detectable similarity to conventional kinases that is found in eukaryotic alpha-kinases PMID:15050379. This domain is shared by EF-2 kinase and the myosin heavy chain kinase A (MHCK A) [[cite:PMID:9054368], [cite:PMID:7822274]]. As in classical kinase, this domain consists of two lobes that bind nucleotide at the interface between them. The N-terminal lobe is very similar in structure to that of classical protein kinases, whereas its C-terminal lobe resembles that of ATP-grasp proteins more closely. A conserved C-terminal glycine rich motif which locates in the region that corresponds to the activation loop of classical kinases is essential for the enzymatic activity PMID:11161216.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• ALPK1
• ALPK2
• ALPK3
• EEF2K
• TRPM6
• TRPM7