Transient receptor potential cation channel M
IPR050927
Definition
The TRPM family comprises ion channels with diverse regulatory mechanisms and functions, including cellular divalent cation homeostasis, sensory perception, and response to environmental changes. Members are involved in mediating calcium and magnesium influx, contributing to membrane depolarization, and are activated by various stimuli such as temperature changes, ligand binding, and intracellular Ca(2+) levels. Some members possess kinase activity, playing roles in phosphorylation processes. The family is implicated in physiological processes like taste transduction, insulin secretion, cell migration, and response to oxidative stress. TRPM channels are also essential in neuronal cell death regulation and immune responses.
8 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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