Seroatlas · Human Serome Atlas

AIFM2

Ferroptosis suppressor protein 1

Also known as: AMID, FLJ14497, FSP1, FSP1_HUMAN, PRG3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRQ8
Gene: AIFM2
Ensembl: ENSG00000042286
Chromosome: 10
Canonical length: 373 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

373 residues, UniProt reviewed canonical sequence.

>Q9BRQ8|AIFM2
     1  MGSQVSVESG ALHVVIVGGG FGGIAAASQL QALNVPFMLV DMKDSFHHNV AALRASVETG
    61  FAKKTFISYS VTFKDNFRQG LVVGIDLKNQ MVLLQGGEAL PFSHLILATG STGPFPGKFN
   121  EVSSQQAAIQ AYEDMVRQVQ RSRFIVVVGG GSAGVEMAAE IKTEYPEKEV TLIHSQVALA
   181  DKELLPSVRQ EVKEILLRKG VQLLLSERVS NLEELPLNEY REYIKVQTDK GTEVATNLVI
   241  LCTGIKINSS AYRKAFESRL ASSGALRVNE HLQVEGHSNV YAIGDCADVR TPKMAYLAGL
   301  HANIAVANIV NSVKQRPLQA YKPGALTFLL SMGRNDGVGQ ISGFYVGRLM VRLTKSRDLF
   361  VSTSWKTMRQ SPP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AIFM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 37 nTPM
breast: 31 nTPM
liver: 21 nTPM
heart muscle: 16 nTPM
thyroid gland: 14 nTPM
blood vessel: 14 nTPM

Single-cell type

adipocytes: 192 nCPM
esophageal apical cells: 171 nCPM
late spermatids: 88 nCPM
colonocytes: 52 nCPM
cardiomyocytes: 42 nCPM
alveolar cells type 1: 41 nCPM

Immune cell

NK-cell: 4 nTPM
gdT-cell: 1.8 nTPM
memory B-cell: 1.7 nTPM
MAIT T-cell: 1.5 nTPM
memory CD8 T-cell: 1.5 nTPM
naive B-cell: 1.5 nTPM

Brain region

choroid plexus: 12 nTPM
hypothalamus: 12 nTPM
medulla oblongata: 12 nTPM
basal ganglia: 11 nTPM
cerebral cortex: 9.9 nTPM
amygdala: 9.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: 0.32
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AIFM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AIFM2 as an antibody target. Whether an autoantibody or antibody against AIFM2 could matter depends on whether native AIFM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AIFM2 is annotated at the cell surface, where native AIFM2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AIFM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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