Seroatlas · Human Serome Atlas

TMEM30A

Cell cycle control protein 50A

Also known as: C6orf67, CC50A_HUMAN, CDC50A, FLJ10856

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NV96
Gene
TMEM30A
Ensembl
ENSG00000112697
Chromosome
6
Canonical length
361 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables aminophospholipid flippase activity and structural molecule activity. Involved in several processes, including phospholipid transport; positive regulation of transport; and xenobiotic transmembrane transport. Located in endoplasmic reticulum; endosome membrane; and plasma membrane. Part of phospholipid-translocating ATPase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

361 residues, UniProt reviewed canonical sequence.

>Q9NV96|TMEM30A
     1  MAMNYNAKDE VDGGPPCAPG GTAKTRRPDN TAFKQQRLPA WQPILTAGTV LPIFFIIGLI
    61  FIPIGIGIFV TSNNIREIEI DYTGTEPSSP CNKCLSPDVT PCFCTINFTL EKSFEGNVFM
   121  YYGLSNFYQN HRRYVKSRDD SQLNGDSSAL LNPSKECEPY RRNEDKPIAP CGAIANSMFN
   181  DTLELFLIGN DSYPIPIALK KKGIAWWTDK NVKFRNPPGG DNLEERFKGT TKPVNWLKPV
   241  YMLDSDPDNN GFINEDFIVW MRTAALPTFR KLYRLIERKS DLHPTLPAGR YSLNVTYNYP
   301  VHYFDGRKRM ILSTISWMGG KNPFLGIAYI AVGSISFLLG VVLLVINHKY RNSSNTADIT
   361  I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM30A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
97 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 97 nTPM
  • liver: 93 nTPM
  • parathyroid gland: 91 nTPM
  • lung: 87 nTPM
  • blood vessel: 85 nTPM
  • thyroid gland: 79 nTPM

Single-cell type

  • corticotrophs: 253 nCPM
  • esophageal apical cells: 235 nCPM
  • neutrophil progenitors: 198 nCPM
  • neutrophils: 174 nCPM
  • alveolar cells type 1: 147 nCPM
  • pancreatic acinar cells: 146 nCPM

Immune cell

  • neutrophil: 139 nTPM
  • non-classical monocyte: 88 nTPM
  • classical monocyte: 86 nTPM
  • intermediate monocyte: 85 nTPM
  • myeloid DC: 79 nTPM
  • total PBMC: 62 nTPM

Brain region

  • white matter: 155 nTPM
  • hypothalamus: 137 nTPM
  • spinal cord: 137 nTPM
  • choroid plexus: 136 nTPM
  • basal ganglia: 128 nTPM
  • hippocampal formation: 123 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0
gnomAD missense Z
1.06
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM30A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM30A as an antibody target. Whether an autoantibody or antibody against TMEM30A could matter depends on whether native TMEM30A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM30A is annotated at the cell surface, where native TMEM30A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM30A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM30A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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