ATP10B

Protein identityUniProt · HPA

UniProt accession

O94823

Gene

ATP10B

Ensembl

ENSG00000118322

Chromosome

5

Canonical length

1461 aa

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables glycosylceramide flippase activity and phosphatidylcholine flippase activity. Involved in lysosomal membrane organization. Located in endoplasmic reticulum; late endosome membrane; and lysosomal membrane. Part of phospholipid-translocating ATPase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1461 residues, UniProt reviewed canonical sequence.

>O94823|ATP10B
     1  MALSVDSSWH RWQWRVRDGF PHCPSETTPL LSPEKGRQSY NLTQQRVVFP NNSIFHQDWE
    61  EVSRRYPGNR TCTTKYTLFT FLPRNLFEQF HRWANLYFLF LVILNWMPSM EVFHREITML
   121  PLAIVLFVIM IKDGMEDFKR HRFDKAINCS NIRIYERKEQ TYVQKCWKDV RVGDFIQMKC
   181  NEIVPADILL LFSSDPNGIC HLETASLDGE TNLKQRCVVK GFSQQEVQFE PELFHNTIVC
   241  EKPNNHLNKF KGYMEHPDQT RTGFGCESLL LRGCTIRNTE MAVGIVIYAG HETKAMLNNS
   301  GPRYKRSKIE RRMNIDIFFC IGILILMCLI GAVGHSIWNG TFEEHPPFDV PDANGSFLPS
   361  ALGGFYMFLT MIILLQVLIP ISLYVSIELV KLGQVFFLSN DLDLYDEETD LSIQCRALNI
   421  AEDLGQIQYI FSDKTGTLTE NKMVFRRCTI MGSEYSHQEN AKRLETPKEL DSDGEEWTQY
   481  QCLSFSARWA QDPATMRSQK GAQPLRRSQS ARVPIQGHYR QRSMGHRESS QPPVAFSSSI
   541  EKDVTPDKNL LTKVRDAALW LETLSDSRPA KASLSTTSSI ADFFLALTIC NSVMVSTTTE
   601  PRQRVTIKPS SKALGTSLEK IQQLFQKLKL LSLSQSFSST APSDTDLGES LGANVATTDS
   661  DERDDASVCS GGDSTDDGGY RSSMWDQGDI LESGSGTSLE EALEAPATDL ARPEFCYEAE
   721  SPDEAALVHA AHAYSFTLVS RTPEQVTVRL PQGTCLTFSL LCTLGFDSVR KRMSVVVRHP
   781  LTGEIVVYTK GADSVIMDLL EDPACVPDIN MEKKLRKIRA RTQKHLDLYA RDGLRTLCIA
   841  KKVVSEEDFR RWASFRREAE ASLDNRDELL METAQHLENQ LTLLGATGIE DRLQEGVPDT
   901  IATLREAGIQ LWVLTGDKQE TAVNIAHSCR LLNQTDTVYT INTENQETCE SILNCALEEL
   961  KQFRELQKPD RKLFGFRLPS KTPSITSEAV VPEAGLVIDG KTLNAIFQGK LEKKFLELTQ
  1021  YCRSVLCCRS TPLQKSMIVK LVRDKLRVMT LSIGDGANDV SMIQAADIGI GISGQEGMQA
  1081  VMSSDFAITR FKHLKKLLLV HGHWCYSRLA RMVVYYLYKN VCYVNLLFWY QFFCGFSSST
  1141  MIDYWQMIFF NLFFTSLPPL VFGVLDKDIS AETLLALPEL YKSGQNSECY NLSTFWISMV
  1201  DAFYQSLICF FIPYLAYKGS DIDVFTFGTP INTISLTTIL LHQAMEMKTW TIFHGVVLLG
  1261  SFLMYFLVSL LYNATCVICN SPTNPYWVME GQLSNPTFYL VCFLTPVVAL LPRYFFLSLQ
  1321  GTCGKSLISK AQKIDKLPPD KRNLEIQSWR SRQRPAPVPE VARPTHHPVS SITGQDFSAS
  1381  TPKSSNPPKR KHVEESVLHE QRCGTECMRD DSCSGDSSAQ LSSGEHLLGP NRIMAYSRGQ
  1441  TDMCRCSKRS SHRRSQSSLT I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP10B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

10

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

43 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.02

gnomAD pLI

0

gnomAD missense Z

-0.09

DepMap mean gene effect

0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• phospholipid translocation
• lysosomal membrane organization

Molecular functions

• ATP binding
• ATP hydrolysis activity
• ATPase-coupled intramembrane lipid transporter activity
• glycosylceramide flippase activity
• magnesium ion binding
• phosphatidylcholine flippase activity

Cellular components

• endoplasmic reticulum
• endoplasmic reticulum membrane
• late endosome membrane
• lysosomal membrane
• membrane
• phospholipid-translocating ATPase complex
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• P-type ATPase
• P-type ATPase, subfamily IV
• P-type ATPase, A domain superfamily
• P-type ATPase, phosphorylation site
• HAD superfamily
• P-type ATPase, transmembrane domain superfamily
• P-type ATPase, cytoplasmic domain N
• P-type ATPase, C-terminal
• P-type ATPase, N-terminal
• HAD-like superfamily
• P-type ATPase, haloacid dehalogenase domain
• P-type ATPase, cytoplasmic domain N
• Phospholipid-translocating ATPase N-terminal
• Phospholipid-translocating P-type ATPase C-terminal

KeywordsUniProt

• ATP-binding
• Endoplasmic reticulum
• Endosome
• Lipid transport
• Lysosome
• Magnesium
• Membrane
• Metal-binding
• Nucleotide-binding
• Translocase
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of ATP10B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TMEM30A