Seroatlas · Human Serome Atlas

ATP11A

Phospholipid-transporting ATPase IH

Also known as: AT11A_HUMAN, ATPIH, ATPIS, KIAA1021

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P98196
Gene: ATP11A
Ensembl: ENSG00000068650
Chromosome: 13
Canonical length: 1134 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

The protein encoded by this gene is an integral membrane ATPase. The encoded protein is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium across membranes. [provided by RefSeq, Apr 2022]

Canonical amino-acid sequenceUniProt

1134 residues, UniProt reviewed canonical sequence.

>P98196|ATP11A
     1  MDCSLVRTLV HRYCAGEENW VDSRTIYVGH REPPPGAEAY IPQRYPDNRI VSSKYTFWNF
    61  IPKNLFEQFR RVANFYFLII FLVQLIIDTP TSPVTSGLPL FFVITVTAIK QGYEDWLRHK
   121  ADNAMNQCPV HFIQHGKLVR KQSRKLRVGD IVMVKEDETF PCDLIFLSSN RGDGTCHVTT
   181  ASLDGESSHK THYAVQDTKG FHTEEDIGGL HATIECEQPQ PDLYKFVGRI NVYSDLNDPV
   241  VRPLGSENLL LRGATLKNTE KIFGVAIYTG METKMALNYQ SKSQKRSAVE KSMNAFLIVY
   301  LCILISKALI NTVLKYMWQS EPFRDEPWYN QKTESERQRN LFLKAFTDFL AFMVLFNYII
   361  PVSMYVTVEM QKFLGSYFIT WDEDMFDEET GEGPLVNTSD LNEELGQVEY IFTDKTGTLT
   421  ENNMEFKECC IEGHVYVPHV ICNGQVLPES SGIDMIDSSP SVNGREREEL FFRALCLCHT
   481  VQVKDDDSVD GPRKSPDGGK SCVYISSSPD EVALVEGVQR LGFTYLRLKD NYMEILNREN
   541  HIERFELLEI LSFDSVRRRM SVIVKSATGE IYLFCKGADS SIFPRVIEGK VDQIRARVER
   601  NAVEGLRTLC VAYKRLIQEE YEGICKLLQA AKVALQDREK KLAEAYEQIE KDLTLLGATA
   661  VEDRLQEKAA DTIEALQKAG IKVWVLTGDK METAAATCYA CKLFRRNTQL LELTTKRIEE
   721  QSLHDVLFEL SKTVLRHSGS LTRDNLSGLS ADMQDYGLII DGAALSLIMK PREDGSSGNY
   781  RELFLEICRS CSAVLCCRMA PLQKAQIVKL IKFSKEHPIT LAIGDGANDV SMILEAHVGI
   841  GVIGKEGRQA ARNSDYAIPK FKHLKKMLLV HGHFYYIRIS ELVQYFFYKN VCFIFPQFLY
   901  QFFCGFSQQT LYDTAYLTLY NISFTSLPIL LYSLMEQHVG IDVLKRDPTL YRDVAKNALL
   961  RWRVFIYWTL LGLFDALVFF FGAYFVFENT TVTSNGQIFG NWTFGTLVFT VMVFTVTLKL
  1021  ALDTHYWTWI NHFVIWGSLL FYVVFSLLWG GVIWPFLNYQ RMYYVFIQML SSGPAWLAIV
  1081  LLVTISLLPD VLKKVLCRQL WPTATERVQT KSQCLSVEQS TIFMLSQTSS SLSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP11A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

lung: 38 nTPM
parathyroid gland: 22 nTPM
heart muscle: 20 nTPM
tongue: 16 nTPM
bone marrow: 16 nTPM
spinal cord: 16 nTPM

Single-cell type

endometrial glandular cells: 1,768 nCPM
endometrial luminal cells: 1,207 nCPM
somatotrophs: 1,157 nCPM
alveolar cells type 2: 1,065 nCPM
alveolar cells type 1: 870 nCPM
transitional alveolar cells: 713 nCPM

Immune cell

neutrophil: 3.1 nTPM
eosinophil: 1.8 nTPM
intermediate monocyte: 1.6 nTPM
naive B-cell: 1.6 nTPM
non-classical monocyte: 1.5 nTPM
classical monocyte: 1.1 nTPM

Brain region

white matter: 95 nTPM
medulla oblongata: 69 nTPM
midbrain: 61 nTPM
thalamus: 60 nTPM
basal ganglia: 60 nTPM
pons: 56 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ATP11A.

Disease | AllUniProt

Conditions ATP11A is implicated in, by any mechanism.

Deafness, autosomal dominant, 84 (DFNA84) MIM:619810
Leukodystrophy, hypomyelinating, 24 (HLD24) MIM:619851
Auditory neuropathy, autosomal dominant 2 (AUNA2) MIM:620384

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 309 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Hearing loss, autosomal dominant 84
Leukodystrophy, hypomyelinating, 24
Autosomal dominant nonsyndromic hearing loss 33
Auditory neuropathy, autosomal dominant 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0
gnomAD missense Z: 1.37
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATP11A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TMEM30A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATP11A as an antibody target. Whether an autoantibody or antibody against ATP11A could matter depends on whether native ATP11A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATP11A is annotated at the cell surface, where native ATP11A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ATP11A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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