Bax inhibitor 1-related
IPR006214
Definition
This entry represents BI-1 and related sequences, including lifeguard proteins, which resemble BI-1 and also act as apoptotic regulators PMID:23888068. This entry also includes bacterial and viral proteins, related to human BAX inhibitor 1, such as Transmembrane protein HWLF3 from human cytomegalovirus, a glycoprotein that contributes to immune evasion by promoting lysosomal degradation of the host stress-inducible NKG2D ligand MICA, thereby diminishing natural killer (NK) cell activation PMID:24787765. Bax inhibitor-1 (BI-1) PMID:8530040 is a suppressor of apoptosis that interacts with BCL2 and BCL-X. Human Bax BI-1 is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments localised to the ER membrane. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest this function. BI-1 also regulates cell death triggered by ER stress [[cite:PMID:19704470], [cite:PMID:23888068], [cite:PMID:22128171]]. BI-1 appears to exert its effect through an interaction with calmodulin PMID:19742129. Crystal structure of a bacterial member reveals that these proteins mediate a calcium leak across the membrane in a pH-dependent manner. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively [[cite:PMID:22128171], [cite:PMID:24904158]].
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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