Seroatlas · Human Serome Atlas

ODF4

Outer dense fiber protein 4

Also known as: CT136, ODFP4_HUMAN, OPPO1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2M2E3
Gene: ODF4
Ensembl: ENSG00000184650
Chromosome: 17
Canonical length: 257 aa
Protein class: Predicted membrane proteins
Subcellular location: Principal piece

OverviewNCBI Gene

This gene encodes a protein that is localized in the outer dense fibers of the tails of mature sperm. This protein is thought to have some important role in the sperm tail. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

257 residues, UniProt reviewed canonical sequence.

>Q2M2E3|ODF4
     1  MDAEYSGNEF PRSEGERDQH QRPGKERKSG EAGWGTGELG QDGRLLSSTL SLSSNRSLGQ
    61  RQNSPLPFQW RITHSFRWMA QVLASELSLV AFILLLVVAF SKKWLDLSRS LFYQRWPVDV
   121  SNRIHTSAHV MSMGLLHFYK SRSCSDLENG KVTFIFSTLM LFPINIWIFE LERNVSIPIG
   181  WSYFIGWLVL ILYFTCAILC YFNHKSFWSL ILSHPSGAVS CSSSFGSVEE SPRAQTITDT
   241  PITQEGVLDP EQKDTHV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ODF4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

testis: 12 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late primary spermatocytes: 115 nCPM
late spermatids: 46 nCPM
early spermatids: 29 nCPM
esophageal apical cells: 14 nCPM
early primary spermatocytes: 9.5 nCPM
esophageal suprabasal cells: 1.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0.01
gnomAD missense Z: 0.93
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

membrane

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ODF4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TMBIM6

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ODF4 as an antibody target. Whether an autoantibody or antibody against ODF4 could matter depends on whether native ODF4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ODF4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ODF4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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