TF

Protein identityUniProt · HPA

UniProt accession

P02787

Gene

TF

Ensembl

ENSG00000091513

Chromosome

3

Canonical length

698 aa

Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Secretome location

Secreted to blood

OverviewNCBI Gene

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

698 residues, UniProt reviewed canonical sequence.

>P02787|TF
     1  MRLAVGALLV CAVLGLCLAV PDKTVRWCAV SEHEATKCQS FRDHMKSVIP SDGPSVACVK
    61  KASYLDCIRA IAANEADAVT LDAGLVYDAY LAPNNLKPVV AEFYGSKEDP QTFYYAVAVV
   121  KKDSGFQMNQ LRGKKSCHTG LGRSAGWNIP IGLLYCDLPE PRKPLEKAVA NFFSGSCAPC
   181  ADGTDFPQLC QLCPGCGCST LNQYFGYSGA FKCLKDGAGD VAFVKHSTIF ENLANKADRD
   241  QYELLCLDNT RKPVDEYKDC HLAQVPSHTV VARSMGGKED LIWELLNQAQ EHFGKDKSKE
   301  FQLFSSPHGK DLLFKDSAHG FLKVPPRMDA KMYLGYEYVT AIRNLREGTC PEAPTDECKP
   361  VKWCALSHHE RLKCDEWSVN SVGKIECVSA ETTEDCIAKI MNGEADAMSL DGGFVYIAGK
   421  CGLVPVLAEN YNKSDNCEDT PEAGYFAIAV VKKSASDLTW DNLKGKKSCH TAVGRTAGWN
   481  IPMGLLYNKI NHCRFDEFFS EGCAPGSKKD SSLCKLCMGS GLNLCEPNNK EGYYGYTGAF
   541  RCLVEKGDVA FVKHQTVPQN TGGKNPDPWA KNLNEKDYEL LCLDGTRKPV EEYANCHLAR
   601  APNHAVVTRK DKEACVHKIL RQQQHLFGSN VTDCSGNFCL FRSETKDLLF RDDTVCLAKL
   661  HDRNTYEKYL GEEYVKAVGN LRKCSTSSLL EACTFRRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.23

Highest tissue expression

7,020 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TF.

Disease | AllUniProt

Conditions TF is implicated in, by any mechanism.

• Atransferrinemia (ATRAF) MIM:209300

Disease | GeneticClinVar

17 pathogenic / likely-pathogenic of 504 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Atransferrinemia
• Transferrin variant D1
• Transferrin variant Bv

Disease | ImmuneIEDB

Conditions an epitope on TF was assayed in.

• rheumatoid arthritis B cell
• brain glioma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.75

gnomAD pLI

0

gnomAD missense Z

1.46

DepMap mean gene effect

0

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• antibacterial humoral response
• cell surface receptor signaling pathway
• cellular response to iron ion
• intracellular iron ion homeostasis
• iron ion transport
• multicellular organismal-level iron ion homeostasis
• osteoclast differentiation
• positive regulation of proteasomal ubiquitin-dependent protein catabolic process
• positive regulation of receptor-mediated endocytosis
• regulation of protein stability

Molecular functions

• enzyme binding
• ferric iron binding
• ferrous iron binding
• iron chaperone activity
• transferrin receptor binding
• transmembrane transporter binding

Cellular components

• apical plasma membrane
• basal part of cell
• basal plasma membrane
• blood microparticle
• cell surface
• clathrin-coated endocytic vesicle membrane
• clathrin-coated pit
• cytoplasmic vesicle
• early endosome
• endocytic vesicle
• endoplasmic reticulum lumen
• endosome membrane
• extracellular exosome
• extracellular region
• extracellular space
• HFE-transferrin receptor complex
• late endosome
• perinuclear region of cytoplasm
• plasma membrane
• recycling endosome
• secretory granule lumen
• vesicle

Protein domainsUniProt · Pfam · InterPro

• Transferrin-like domain
• Transferrin
• Transferrin family, iron binding site
• Transferrin
• Serotransferrin, mammalian

KeywordsUniProt

• Disulfide bond
• Glycoprotein
• Ion transport
• Iron
• Iron transport
• Metal-binding
• Methylation
• Phosphoprotein
• Repeat
• Secreted
• Signal
• Transport

InteractionsUniProt · HPA

Protein binding partners of TF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TFRC
• HPSE