TAF13

Protein identityUniProt · HPA

UniProt accession

Q15543

Gene

TAF13

Ensembl

ENSG00000197780

Chromosome

1

Canonical length

124 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli

OverviewNCBI Gene

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

124 residues, UniProt reviewed canonical sequence.

>Q15543|TAF13
     1  MADEEEDPTF EEENEEIGGG AEGGQGKRKR LFSKELRCMM YGFGDDQNPY TESVDILEDL
    61  VIEFITEMTH KAMSIGRQGR VQVEDIVFLI RKDPRKFARV KDLLTMNEEL KRARKAFDEA
   121  NYGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAF13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.49

Highest tissue expression

90 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TAF13.

Disease | AllUniProt

Conditions TAF13 is implicated in, by any mechanism.

• Intellectual developmental disorder, autosomal recessive 60 (MRT60) MIM:617432

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 18 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Intellectual disability, autosomal recessive 60

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.09

gnomAD pLI

0.02

gnomAD missense Z

1.26

DepMap mean gene effect

-0.49

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• DNA-templated transcription initiation
• mRNA transcription by RNA polymerase II
• positive regulation of transcription initiation by RNA polymerase II
• RNA polymerase II preinitiation complex assembly
• transcription by RNA polymerase II
• transcription initiation at RNA polymerase II promoter

Molecular functions

• DNA binding
• protein heterodimerization activity
• RNA polymerase II general transcription initiation factor activity
• TBP-class protein binding

Cellular components

• nucleolus
• nucleoplasm
• nucleus
• transcription factor TFIID complex

Protein domainsUniProt · Pfam · InterPro

• Transcription initiation factor IID, subunit 13
• Histone-fold
• Transcription initiation factor IID, 18kD subunit

KeywordsUniProt

• Intellectual disability
• Nucleus
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of TAF13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TAF11
• TBP
• TAF3
• TAF8