TAF11

Protein identityUniProt · HPA

UniProt accession

Q15544

Gene

TAF11

Ensembl

ENSG00000064995

Chromosome

6

Canonical length

211 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

211 residues, UniProt reviewed canonical sequence.

>Q15544|TAF11
     1  MDDAHESPSD KGGETGESDE TAAVPGDPGA TDTDGIPEET DGDADVDLKE AAAEEGELES
    61  QDVSDLTTVE REDSSLLNPA AKKLKIDTKE KKEKKQKVDE DEIQKMQILV SSFSEEQLNR
   121  YEMYRRSAFP KAAIKRLIQS ITGTSVSQNV VIAMSGISKV FVGEVVEEAL DVCEKWGEMP
   181  PLQPKHMREA VRRLKSKGQI PNSKHKKIIF F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAF11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.55

Highest tissue expression

24 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.83

gnomAD pLI

0.11

gnomAD missense Z

0.99

DepMap mean gene effect

-0.27

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• host-mediated activation of viral transcription
• mRNA transcription by RNA polymerase II
• positive regulation of transcription initiation by RNA polymerase II
• RNA polymerase II preinitiation complex assembly
• transcription by RNA polymerase II
• transcription initiation at RNA polymerase II promoter

Molecular functions

• nuclear thyroid hormone receptor binding
• nuclear vitamin D receptor binding
• protein heterodimerization activity
• RNA polymerase II general transcription initiation factor activity
• TBP-class protein binding
• transcription coactivator activity

Cellular components

• Golgi apparatus
• nucleoplasm
• nucleus
• transcription factor TFIID complex

Protein domainsUniProt · Pfam · InterPro

• TAFII28-like protein domain
• Histone-fold
• Transcription initiation factor TFIID subunit 11-like
• hTAFII28-like protein conserved region

KeywordsUniProt

• Acetylation
• Nucleus
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of TAF11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TBP
• TAF13
• TAF7
• TAF8