TBPL2
TATA box-binding protein-like 2
Also known as: TBP2, TBPL2_HUMAN, TRF3
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6SJ96
- Gene
- TBPL2
- Ensembl
- ENSG00000182521
- Chromosome
- 14
- Canonical length
- 343 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in DNA-templated transcription initiation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
343 residues, UniProt reviewed canonical sequence.
>Q6SJ96|TBPL2
1 MEQEETYLEL YLDQCAAQDG LAPPRSPLFS PVVPYDMYIL NASNPDTAFN SNPEVKETSG
61 DFSSVDLSFL PDEVTQENKD QPVISKHETE ENSESQSPQS RLPSPSEQDV GLGLNSSSLS
121 NSHSQLHPGD TDSVQPSPEK PNSDSLSLAS ITPMTPMTPI SECCGIVPQL QNIVSTVNLA
181 CKLDLKKIAL HAKNAEYNPK RFAAVIMRIR EPRTTALIFS SGKMVCTGAK SEEQSRLAAR
241 KYARVVQKLG FPARFLDFKI QNMVGSCDVR FPIRLEGLVL THQQFSSYEP ELFPGLIYRM
301 VKPRIVLLIF VSGKVVLTGA KERSEIYEAF ENIYPILKGF KKALocalizationUniProt · AlphaFold · HPA
Whether an antibody against TBPL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.46
- Highest tissue expression
- 1.4 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 1.4 nTPM
- skin: 1.2 nTPM
- testis: 0.7 nTPM
- endometrium: 0.6 nTPM
- ovary: 0.6 nTPM
- appendix: 0.5 nTPM
Single-cell type
- oocytes: 101 nCPM
- early spermatids: 7.8 nCPM
- late primary spermatocytes: 4.9 nCPM
- colonocytes: 3.6 nCPM
- early primary spermatocytes: 2.6 nCPM
- granulosa cells: 2.4 nCPM
Immune cell
- basophil: 0.2 nTPM
- gdT-cell: 0.1 nTPM
- neutrophil: 0.1 nTPM
- NK-cell: 0.1 nTPM
- plasmacytoid DC: 0.1 nTPM
- classical monocyte: 0 nTPM
Brain region
- cerebellum: 5.2 nTPM
- white matter: 4.2 nTPM
- medulla oblongata: 3.8 nTPM
- cerebral cortex: 3.7 nTPM
- pons: 2.9 nTPM
- amygdala: 2.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.39
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.32
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TBPL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TBPL2 as an antibody target. Whether an autoantibody or antibody against TBPL2 could matter depends on whether native TBPL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TBPL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TBPL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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