SPO16
Protein SPO16 homolog
Also known as: C1orf146, SPO16_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5VVC0
- Gene
- SPO16
- Ensembl
- ENSG00000203910
- Chromosome
- 1
- Canonical length
- 180 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Centriolar satellite
- Quaternary structure
- Homooligomer
OverviewNCBI Gene
Predicted to be involved in reciprocal meiotic recombination and synaptonemal complex assembly. Predicted to be active in chromosome. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
180 residues, UniProt reviewed canonical sequence.
>Q5VVC0|SPO16
1 MAESGKEKIK WTTTIIISSS LKSYEVATAL ENRSHKVRYS DSVENGSIIF SLSGVAFLLM
61 DTKECLLSTE EIFLAKIEKF INIHQNSFLV LSAALHGPEE WKLMFRIQQR FLGCNLRILP
121 VHNTVNAINL MCTIAKTTSK PYIDSICYRM ITAKAYIIEQ SPVWKTLQKI KLNSDSVNPNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPO16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 7 nTPM
Expression across tissuesHPA
Tissue
- testis: 7 nTPM
- retina: 1.9 nTPM
- skin: 0.5 nTPM
- pancreas: 0.3 nTPM
- appendix: 0.2 nTPM
- cerebral cortex: 0.2 nTPM
Single-cell type
- early primary spermatocytes: 111 nCPM
- oocytes: 60 nCPM
- differentiating spermatogonia: 19 nCPM
- undifferentiated spermatogonia: 13 nCPM
- myonuclei: 6.4 nCPM
- cardiomyocytes: 5.7 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 4.3 nTPM
- cerebral cortex: 2.7 nTPM
- basal ganglia: 2.3 nTPM
- white matter: 2.2 nTPM
- hypothalamus: 2 nTPM
- thalamus: 1.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.25
- gnomAD pLI
- 0
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Protein SPO16 homolog
- Protein SPO16 homolog
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SPO16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPO16 as an antibody target. Whether an autoantibody or antibody against SPO16 could matter depends on whether native SPO16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPO16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SPO16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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