Seroatlas · Human Serome Atlas

PSMA8

Proteasome subunit alpha-type 8

Also known as: MGC26605, PSMA7L, PSMA8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAA3
Gene: PSMA8
Ensembl: ENSG00000154611
Chromosome: 18
Canonical length: 256 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Vesicles,Principal piece

OverviewNCBI Gene

Predicted to be involved in meiotic cell cycle and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in extracellular exosome and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

256 residues, UniProt reviewed canonical sequence.

>Q8TAA3|PSMA8
     1  MASRYDRAIT VFSPDGHLFQ VEYAQEAVKK GSTAVGIRGT NIVVLGVEKK SVAKLQDERT
    61  VRKICALDDH VCMAFAVLTI FIGLTADARV VINRARVECQ SHKLTVEDPV TVEYITRFIA
   121  TLKQKYTQSN GRRPFGISAL IVGFDDDGIS RLYQTDPSGT YHAWKANAIG RSAKTVREFL
   181  EKNYTEDAIA SDSEAIKLAI KALLEVVQSG GKNIELAIIR RNQPLKMFSA KEVELYVTEI
   241  EKEKEEAEKK KSKKSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMA8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

testis: 16 nTPM
tonsil: 1.6 nTPM
lymph node: 1.3 nTPM
thymus: 0.5 nTPM
appendix: 0.4 nTPM
placenta: 0.2 nTPM

Single-cell type

early primary spermatocytes: 288 nCPM
late primary spermatocytes: 126 nCPM
sertoli cells: 32 nCPM
differentiating spermatogonia: 13 nCPM
undifferentiated spermatogonia: 11 nCPM
early spermatids: 5.9 nCPM

Immune cell

naive CD8 T-cell: 1.9 nTPM
T-reg: 1.6 nTPM
memory B-cell: 1.4 nTPM
memory CD8 T-cell: 1.2 nTPM
naive B-cell: 1.2 nTPM
naive CD4 T-cell: 0.9 nTPM

Brain region

hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM
pons: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: 0.37
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMA8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SYCE3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMA8 as an antibody target. Whether an autoantibody or antibody against PSMA8 could matter depends on whether native PSMA8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMA8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMA8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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