TEX12
Testis-expressed protein 12
Also known as: TEX12_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BXU0
- Gene
- TEX12
- Ensembl
- ENSG00000150783
- Chromosome
- 11
- Canonical length
- 123 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Centrosome,Basal body
OverviewNCBI Gene
This gene is similar to a mouse gene that is expressed in the testis. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
123 residues, UniProt reviewed canonical sequence.
>Q9BXU0|TEX12
1 MMANHLVKPD NRNCKRPREL ESPVPDSPQL SSLGKSDSSF SEISGLFYKD EALEKDLNDV
61 SKEINLMLST YAKLLSERAA VDASYIDEID ELFKEANAIE NFLIQKREFL RQRFTVIANT
121 LHRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TEX12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.58
- Highest tissue expression
- 19 nTPM
Expression across tissuesHPA
Tissue
- testis: 19 nTPM
- retina: 8 nTPM
- skeletal muscle: 0.9 nTPM
- skin: 0.7 nTPM
- tongue: 0.6 nTPM
- duodenum: 0.5 nTPM
Single-cell type
- early primary spermatocytes: 4.3 nCPM
- late primary spermatocytes: 0.7 nCPM
- early spermatids: 0.2 nCPM
- undifferentiated spermatogonia: 0.2 nCPM
- differentiating spermatogonia: 0.1 nCPM
- lactotrophs: 0.1 nCPM
Immune cell
- eosinophil: 0.2 nTPM
- memory CD8 T-cell: 0.1 nTPM
- neutrophil: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- cerebellum: 1.6 nTPM
- cerebral cortex: 1.3 nTPM
- thalamus: 0.9 nTPM
- amygdala: 0.8 nTPM
- basal ganglia: 0.8 nTPM
- choroid plexus: 0.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.78
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.3
- DepMap mean gene effect
- 0.18
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Testis-expressed sequence 12 protein
- Testis-expressed 12
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TEX12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TEX12 as an antibody target. Whether an autoantibody or antibody against TEX12 could matter depends on whether native TEX12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TEX12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TEX12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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