Seroatlas · Human Serome Atlas

SURF6

Surfeit locus protein 6

Also known as: FLJ30322, RRP14, SURF6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75683
Gene
SURF6
Ensembl
ENSG00000148296
Chromosome
9
Canonical length
361 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Nucleoli rim,Mitotic chromosome

OverviewNCBI Gene

This gene encodes a conserved protein that is localized to the nucleolus. The encoded protein may function as a nucleolar-matrix protein with nucleic acid-binding properties. There is a pseudogene for this gene on chromosome Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

361 residues, UniProt reviewed canonical sequence.

>O75683|SURF6
     1  MASLLAKDAY LQSLAKKICS HSAPEQQART RAGKTQGSET AGPPKKKRKK TQKKFRKREE
    61  KAAEHKAKSL GEKSPAASGA RRPEAAKEEA AWASSSAGNP ADGLATEPES VFALDVLRQR
   121  LHEKIQEARG QGSAKELSPA ALEKRRRRKQ ERDRKKRKRK ELRAKEKARK AEEATEAQEV
   181  VEATPEGACT EPREPPGLIF NKVEVSEDEP ASKAQRRKEK RQRVKGNLTP LTGRNYRQLL
   241  ERLQARQSRL DELRGQDEGK AQELEAKMKW TNLLYKAEGV KIRDDERLLQ EALKRKEKRR
   301  AQRQRRWEKR TAGVVEKMQQ RQDRRRQNLR RKKAARAERR LLRARKKGRI LPQDLERAGL
   361  V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SURF6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 18 nTPM
  • midbrain: 17 nTPM
  • spinal cord: 16 nTPM
  • amygdala: 15 nTPM
  • hippocampal formation: 15 nTPM
  • basal ganglia: 15 nTPM

Single-cell type

  • proximal tubule cells: 14 nCPM
  • microglia: 13 nCPM
  • papillary tip epithelial cells: 13 nCPM
  • other brain neurons: 13 nCPM
  • paneth cells: 12 nCPM
  • renal connecting tubule cells: 11 nCPM

Immune cell

  • plasmacytoid DC: 6 nTPM
  • naive CD4 T-cell: 5.2 nTPM
  • naive B-cell: 5.1 nTPM
  • memory B-cell: 4.6 nTPM
  • MAIT T-cell: 4.5 nTPM
  • naive CD8 T-cell: 4.4 nTPM

Brain region

  • cerebellum: 13 nTPM
  • amygdala: 12 nTPM
  • thalamus: 12 nTPM
  • white matter: 12 nTPM
  • midbrain: 12 nTPM
  • pons: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0
gnomAD missense Z
-0.27
DepMap mean gene effect
-0.59
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Surfeit locus 6
  • Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain
  • Surfeit locus protein 6

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SURF6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SURF6 as an antibody target. Whether an autoantibody or antibody against SURF6 could matter depends on whether native SURF6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SURF6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SURF6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SURF6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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