Seroatlas · Human Serome Atlas

RRS1

Ribosome biogenesis regulatory protein homolog

Also known as: KIAA0112, RRS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15050
Gene
RRS1
Ensembl
ENSG00000179041
Chromosome
8
Canonical length
365 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli

OverviewNCBI Gene

Enables 5S rRNA binding activity. Involved in several processes, including mitotic metaphase chromosome alignment; protein localization to nucleolus; and ribosomal large subunit assembly. Located in condensed nuclear chromosome; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

365 residues, UniProt reviewed canonical sequence.

>Q15050|RRS1
     1  MEGQSVEELL AKAEQDEAEK LQRITVHKEL ELQFDLGNLL ASDRNPPTGL RCAGPTPEAE
    61  LQALARDNTQ LLINQLWQLP TERVEEAIVA RLPEPTTRLP REKPLPRPRP LTRWQQFARL
   121  KGIRPKKKTN LVWDEVSGQW RRRWGYQRAR DDTKEWLIEV PGNADPLEDQ FAKRIQAKKE
   181  RVAKNELNRL RNLARAHKMQ LPSAAGLHPT GHQSKEELGR AMQVAKVSTA SVGRFQERLP
   241  KEKVPRGSGK KRKFQPLFGD FAAEKKNQLE LLRVMNSKKP QLDVTRATNK QMREEDQEEA
   301  AKRRKMSQKG KRKGGRQGPG GKRKGGPPSQ GGKRKGGLGG KMNSGPPGLG GKRKGGQRPG
   361  GKRRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RRS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
47 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 47 nTPM
  • pancreas: 39 nTPM
  • stomach: 18 nTPM
  • adipose tissue: 18 nTPM
  • esophagus: 18 nTPM
  • endometrium: 17 nTPM

Single-cell type

  • erythrocyte progenitors: 11 nCPM
  • megakaryocyte-erythroid progenitors: 9.1 nCPM
  • suprabasal keratinocytes: 9.1 nCPM
  • fallopian secretory cells: 8.6 nCPM
  • basal keratinocytes: 8.1 nCPM
  • megakaryocyte progenitors: 8 nCPM

Immune cell

  • MAIT T-cell: 25 nTPM
  • myeloid DC: 23 nTPM
  • naive CD8 T-cell: 19 nTPM
  • intermediate monocyte: 18 nTPM
  • memory CD4 T-cell: 18 nTPM
  • NK-cell: 17 nTPM

Brain region

  • medulla oblongata: 26 nTPM
  • thalamus: 20 nTPM
  • choroid plexus: 17 nTPM
  • midbrain: 17 nTPM
  • spinal cord: 16 nTPM
  • amygdala: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0.18
gnomAD missense Z
0.2
DepMap mean gene effect
-1.22
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Ribosomal biogenesis regulatory protein
  • Ribosome biogenesis regulatory protein (RRS1)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RRS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RRS1 as an antibody target. Whether an autoantibody or antibody against RRS1 could matter depends on whether native RRS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RRS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RRS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RRS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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