Seroatlas · Human Serome Atlas

SPIN3

Spindlin-3

Also known as: SPIN3_HUMAN, TDRD27

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JUX0
Gene: SPIN3
Ensembl: ENSG00000204271
Chromosome: X
Canonical length: 258 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables methylated histone binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in membrane. Predicted to be active in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

258 residues, UniProt reviewed canonical sequence.

>Q5JUX0|SPIN3
     1  MKTPFGKAAA GQRSRTGAGH GSVSVTMIKR KAAHKKHRSR PTSQPRGNIV GCRIQHGWKD
    61  GDEPLTQWKG TVLDQVPVNP SLYLIKYDGF DCVYGLELHR DERVSSLEVL PNRVASSRIS
   121  DTHLAEIMVG KAVEHIFETE EGSKNEWRGM VLAQAPVMNT WFYITYEKDP VLYMYQLLDD
   181  YKDGDLRILQ DSNDSPLAER EPGEVIDSLV GKQVEYAKDD GSKRTGMVIH QVEAKPSVYF
   241  IKFDDDFHIY VYDLVKTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPIN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 14 nTPM
hypothalamus: 9.5 nTPM
basal ganglia: 9.3 nTPM
cerebral cortex: 8.9 nTPM
pituitary gland: 8.2 nTPM
pancreas: 8 nTPM

Single-cell type

brain excitatory neurons: 59 nCPM
adipocytes: 53 nCPM
brain inhibitory neurons: 51 nCPM
oligodendrocyte progenitor cells: 42 nCPM
other brain neurons: 38 nCPM
tuft cells: 35 nCPM

Immune cell

NK-cell: 2.2 nTPM
naive CD4 T-cell: 2 nTPM
memory CD4 T-cell: 1.7 nTPM
basophil: 1.5 nTPM
memory B-cell: 1.1 nTPM
total PBMC: 1 nTPM

Brain region

hypothalamus: 13 nTPM
cerebellum: 13 nTPM
basal ganglia: 12 nTPM
cerebral cortex: 11 nTPM
hippocampal formation: 10 nTPM
white matter: 9.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0.78
gnomAD missense Z: 1.09
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

histone H3K4me3 reader activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of SPIN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SPINDOC

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPIN3 as an antibody target. Whether an autoantibody or antibody against SPIN3 could matter depends on whether native SPIN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPIN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPIN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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