Seroatlas · Human Serome Atlas

SPIN4

Spindlin-4

Also known as: FLJ44984, SPIN4_HUMAN, TDRD28

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q56A73
Gene
SPIN4
Ensembl
ENSG00000186767
Chromosome
X
Canonical length
249 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centrosome,Cytosol

OverviewNCBI Gene

Enables methylated histone binding activity. Involved in negative regulation of cell population proliferation and positive regulation of canonical Wnt signaling pathway. Located in chromatin; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

249 residues, UniProt reviewed canonical sequence.

>Q56A73|SPIN4
     1  MSPPTVPPMG VDGVSAYLMK KRHTHRKQRR KPTFLTRRNI VGCRIQHGWK EGNEPVEQWK
    61  GTVLEQVSVK PTLYIIKYDG KDSVYGLELH RDKRVLALEI LPERVPTPRI DSRLADSLIG
   121  KAVEHVFEGE HGTKDEWKGM VLARAPVMDT WFYITYEKDP VLYMYTLLDD YKDGDLRIIP
   181  DSNYYFPTAE QEPGEVVDSL VGKQVEHAKD DGSKRTGIFI HQVVAKPSVY FIKFDDDIHI
   241  YVYGLVKTP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPIN4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
9.6 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 9.6 nTPM
  • salivary gland: 6.8 nTPM
  • esophagus: 5.5 nTPM
  • tonsil: 5.2 nTPM
  • placenta: 4.1 nTPM
  • rectum: 3.8 nTPM

Single-cell type

  • podocytes: 5.9 nCPM
  • proximal tubule cells: 3 nCPM
  • loop of henle epithelial cells: 2.3 nCPM
  • distal convoluted tubule cells: 2.2 nCPM
  • renal connecting tubule cells: 2.1 nCPM
  • renal collecting duct intercalated cells: 1.5 nCPM

Immune cell

  • NK-cell: 2.6 nTPM
  • eosinophil: 1.6 nTPM
  • intermediate monocyte: 0.9 nTPM
  • classical monocyte: 0.8 nTPM
  • non-classical monocyte: 0.8 nTPM
  • basophil: 0.7 nTPM

Brain region

  • hypothalamus: 8.7 nTPM
  • midbrain: 6.4 nTPM
  • choroid plexus: 5.6 nTPM
  • medulla oblongata: 5.6 nTPM
  • white matter: 5.5 nTPM
  • pons: 5.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SPIN4.

Disease | AllUniProt

Conditions SPIN4 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 15 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Lui-Jee-Baron syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0.76
gnomAD missense Z
1.58
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPIN4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPIN4 as an antibody target. Whether an autoantibody or antibody against SPIN4 could matter depends on whether native SPIN4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPIN4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPIN4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPIN4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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