TBPL1

Protein identityUniProt · HPA

UniProt accession

P62380

Gene

TBPL1

Ensembl

ENSG00000028839

Chromosome

6

Canonical length

186 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

186 residues, UniProt reviewed canonical sequence.

>P62380|TBPL1
     1  MDADSDVALD ILITNVVCVF RTRCHLNLRK IALEGANVIY KRDVGKVLMK LRKPRITATI
    61  WSSGKIICTG ATSEEEAKFG ARRLARSLQK LGFQVIFTDF KVVNVLAVCN MPFEIRLPEF
   121  TKNNRPHASY EPELHPAVCY RIKSLRATLQ IFSTGSITVT GPNVKAVATA VEQIYPFVFE
   181  SRKEIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBPL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

118 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.69

gnomAD pLI

0.38

gnomAD missense Z

2.5

DepMap mean gene effect

0.09

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• acrosome assembly
• DNA-templated transcription initiation
• dTTP biosynthetic process
• spermatid nucleus differentiation
• transcription by RNA polymerase II

Molecular functions

• RNA polymerase II core promoter sequence-specific DNA binding
• RNA polymerase II general transcription initiation factor activity
• general transcription initiation factor activity

Cellular components

• cytoplasm
• male germ cell nucleus
• transcription factor TFIIA complex

Protein domainsUniProt · Pfam · InterPro

• TATA-box binding protein
• TBP domain superfamily
• Transcription factor TFIID (or TATA-binding protein, TBP)
• TATA-Box binding protein-like 1

KeywordsUniProt

• Cytoplasm
• DNA-binding
• Nucleus
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of TBPL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SPATA24
• GTF2A1
• GTF2A2