Seroatlas · Human Serome Atlas

CEP72

Centrosomal protein of 72 kDa

Also known as: CEP72_HUMAN, FLJ10565, KIAA1519

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P209
Gene: CEP72
Ensembl: ENSG00000112877
Chromosome: 5
Canonical length: 647 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centriolar satellite,Centrosome,Basal body

OverviewNCBI Gene

The product of this gene is a member of the leucine-rich-repeat (LRR) superfamily of proteins. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

647 residues, UniProt reviewed canonical sequence.

>Q9P209|CEP72
     1  MARAGPRLVL SEEAVRAKSG LGPHRDLAEL QSLSIPGTYQ EKITHLGHSL MSLTGLKSLD
    61  LSRNSLVSLE GIQYLTALES LNLYYNCISS LAEVFRLHAL TELVDVDFRL NPVVKVEPDY
   121  RLFVVHLLPK LQQLDDRPVR ASERKASRLH FASEDSLDSK ESVPASLKEG RPHHPRAKCT
   181  EALAKQSLVM DADDEAVLNL IAECEWDLGR PPGSTSFSQK GREADSRGSQ ESRHLLSPQL
   241  VQYQCGDSGK QGRETRRSSC RGCCLEKMPW SQLCGELPPL YGAEPEASRA PRPHTYFTPH
   301  PDSMDTEDSA SSQKLDLSGE MVPGPLPAPG KCRKRRMPVG RFQTFSDQEG LGCPERTHGS
   361  SVPKESLSRQ DSSESRNGRT LSQPEASETE EQRSRGVTDT REPSPGSHSA LPGKKTALQA
   421  ALLETLLDLV DRSWGGCRSL HSNEAFLAQA RHILSSVEEF TAAQDSSAMV GEDVGSLALE
   481  SKSLQSRLAE QQQQHAREMS EVTAELHHTH KELDDLRQHL DKSLEENSRL KSLLLSMKKE
   541  VKSADTAATL NLQIAGLQTS VKRLCGEIVE LKQHLEHYDK IQELTQMLQE SHSSLVSTNE
   601  HLLQELSQVR AQHRAEVEQM HWSYQELKKT MALFPHSSAS HGGCQAC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP72 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 7.1 nTPM

Expression across tissuesHPA

Tissue

testis: 7.1 nTPM
bone marrow: 2.9 nTPM
cerebellum: 2.9 nTPM
thymus: 2.8 nTPM
lymph node: 2.5 nTPM
basal ganglia: 2.4 nTPM

Single-cell type

melanocytes: 182 nCPM
cardiomyocytes: 72 nCPM
epicardial cells: 41 nCPM
early primary spermatocytes: 32 nCPM
oocytes: 23 nCPM
gastric progenitor cells: 18 nCPM

Immune cell

NK-cell: 4.5 nTPM
MAIT T-cell: 1.7 nTPM
naive B-cell: 1.6 nTPM
naive CD4 T-cell: 1.6 nTPM
naive CD8 T-cell: 1.6 nTPM
T-reg: 1.5 nTPM

Brain region

white matter: 4.6 nTPM
cerebellum: 4.1 nTPM
cerebral cortex: 4 nTPM
basal ganglia: 3.8 nTPM
amygdala: 3.4 nTPM
hippocampal formation: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: -0.89
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEP72 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP72 as an antibody target. Whether an autoantibody or antibody against CEP72 could matter depends on whether native CEP72 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP72 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP72 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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