BDNF

Protein identityUniProt · HPA

UniProt accession

P23560

Gene

BDNF

Ensembl

ENSG00000176697

Chromosome

11

Canonical length

247 aa

Protein class

Cancer-related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins

Secretome location

Secreted to blood

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

247 residues, UniProt reviewed canonical sequence.

>P23560|BDNF
     1  MTILFLTMVI SYFGCMKAAP MKEANIRGQG GLAYPGVRTH GTLESVNGPK AGSRGLTSLA
    61  DTFEHVIEEL LDEDQKVRPN EENNKDADLY TSRVMLSSQV PLEPPLLFLL EEYKNYLDAA
   121  NMSMRVRRHS DPARRGELSV CDSISEWVTA ADKKTAVDMS GGTVTVLEKV PVSKGQLKQY
   181  FYETKCNPMG YTKEGCRGID KRHWNSQCRT TQSYVRALTM DSKKRIGWRF IRIDTSCVCT
   241  LTIKRGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BDNF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

4.9 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BDNF.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 152 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Inborn genetic diseases
• Obesity

ReferencesPubMed · IEDB

Publications for BDNF from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.52

gnomAD pLI

0.66

gnomAD missense Z

1.94

DepMap mean gene effect

-0.07

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• axon guidance
• brain-derived neurotrophic factor receptor signaling pathway
• cell surface receptor protein tyrosine kinase signaling pathway
• collateral sprouting
• modulation of chemical synaptic transmission
• negative regulation of apoptotic signaling pathway
• negative regulation of myotube differentiation
• negative regulation of neuron apoptotic process
• nerve development
• nerve growth factor signaling pathway
• nervous system development
• neuron projection morphogenesis
• positive regulation of brain-derived neurotrophic factor receptor signaling pathway
• positive regulation of collateral sprouting
• positive regulation of neuron projection development
• positive regulation of synapse assembly
• regulation of protein localization to cell surface
• synapse assembly

Molecular functions

• growth factor activity
• nerve growth factor receptor binding

Cellular components

• axon
• cytoplasm
• dendrite
• endoplasmic reticulum lumen
• extracellular region
• extracellular space
• perinuclear region of cytoplasm
• synaptic vesicle

Protein domainsUniProt · Pfam · InterPro

• Nerve growth factor-related
• Nerve growth factor conserved site
• Nerve growth factor-like
• Cystine-knot cytokine
• Nerve growth factor family
• Brain-derived neurotrophic factor

KeywordsUniProt

• Alternative promoter usage
• Cleavage on pair of basic residues
• Disulfide bond
• Glycoprotein
• Growth factor
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of BDNF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SORCS2
• HAP1
• NTF3
• NTF4