Sortilin, N-terminal

Definition

Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of the vacuolar protein sorting 10 protein domain (Vps10-D) receptor family that binds neurotrophic factors and neuropeptides PMID:25345507. This entry represents a domain that constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage [[cite:PMID:9013611], [cite:PMID:9756851]]. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or β-hairpin turns in it PMID:19122660. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)-6 and brain-derived neurotrophic factor (BDNF)-7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1 [[cite:PMID:19122660], [cite:PMID:10085125]].

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• SORCS1
• SORCS2
• SORCS3
• SORL1
• SORT1